Rabbit Polyclonal FBXL16 Antibody

The FBXL16 antibody is a research tool designed to detect and study the F-box and leucine-rich repeat protein 16 (FBXL16), a member of the F-box protein family. These proteins are critical components of the SCF (SKP1-CUL1-F-box) ubiquitin ligase complex, which regulates protein degradation via the ubiquitin-proteasome system. FBXL16 contains an F-box domain that mediates interaction with SKP1. linking it to the core ubiquitination machinery, and leucine-rich repeats (LRRs) that likely participate in substrate recognition. Though less characterized than other F-box proteins, FBXL16 is implicated in cellular processes such as cell cycle regulation, apoptosis, and cancer progression. Studies suggest it may target specific proteins for ubiquitination, influencing their stability or activity. Researchers use FBXL16 antibodies in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to explore its expression patterns, subcellular localization, and interactions under physiological or pathological conditions. These antibodies are often validated for specificity using knockout controls or siRNA-mediated depletion. Commercially available FBXL16 antibodies are typically raised in hosts like rabbits or mice, with clonal variants (monoclonal/polyoclonal) tailored for specific applications. Its role in diseases, particularly cancer, remains an active area of investigation, with potential links to tumor suppression or oncogenic pathways depending on cellular context.