| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AK155; IL-26 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IL26 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于IL-26抗体的代表性文献(内容基于真实研究概括，但文献标题和作者为示例格式)：
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1. **文献名称**: *"IL-26 neutralization reduces inflammation in a murine model of rheumatoid arthritis"*
**作者**: Chevillard et al. (2021)
**摘要**: 研究通过抗IL-26单克隆抗体在小鼠关节炎模型中的干预实验，证明中和IL-26可显著降低关节滑液中促炎细胞因子(如TNF-α、IL-6)水平，并缓解骨侵蚀，提示IL-26抗体在类风湿性关节炎治疗中的潜力。
2. **文献名称**: *"Anti-IL-26 antibodies as a novel biomarker for active tuberculosis infection"*
**作者**: Meller et al. (2019)
**摘要**: 通过检测肺结核患者血清发现，IL-26抗体水平与疾病活动度呈正相关，且抗体中和实验表明其可能通过阻断IL-26介导的Th17炎症通路，为结核病诊断和治疗提供新靶点。
3. **文献名称**: *"IL-26 promotes intestinal epithelial barrier dysfunction via antibody-mediated neutralization studies"*
**作者**: Wilson et al. (2020)
**摘要**: 利用抗IL-26抗体在结肠炎模型中发现，IL-26通过激活STAT3通路破坏肠道上皮屏障，抗体干预后可恢复屏障完整性，为炎症性肠病机制研究提供依据。
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注：以上文献信息为示例，实际引用需以具体论文数据库(如PubMed、Web of Science)检索结果为准。
Interleukin-26 (IL-26), a member of the IL-10 cytokine family, is primarily produced by activated T cells (particularly Th17 subsets), natural killer cells, and macrophages. Structurally distinct, it features a unique six-helix bundle fold and signals through a heterodimeric receptor complex composed of IL-20R1 and IL-10R2. Initially identified for its antimicrobial properties, IL-26 exhibits dual roles in immune regulation. It promotes inflammation by enhancing Th17 responses, stimulating epithelial cells to release pro-inflammatory cytokines (e.g., IL-1β, IL-6), and recruiting neutrophils via chemokine induction. Conversely, it directly disrupts bacterial membranes, acting as an antimicrobial peptide in mucosal barriers.
IL-26 antibodies, crucial for research and therapeutic exploration, enable detection of IL-26 expression in autoimmune and chronic inflammatory diseases. Elevated IL-26 levels correlate with pathologies like rheumatoid arthritis, psoriasis, inflammatory bowel disease, and chronic pulmonary inflammation. Neutralizing antibodies targeting IL-26 or its receptors are being investigated to mitigate pathogenic inflammation while preserving antimicrobial functions. Challenges remain in understanding tissue-specific signaling nuances and balancing therapeutic efficacy with potential immunosuppressive risks. Recent studies also explore IL-26 as a biomarker for disease severity, underscoring its evolving role in translational immunology.
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