| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C49A; FISP; MDA7; MOB5; ST16; IL10B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IL24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与IL24抗体相关的文献示例(注：文献为虚拟示例，实际引用请核实)：
1. **"IL-24 antibody enhances radiation-induced apoptosis in human melanoma cells"**
*作者：Smith A, et al.*
摘要：研究证明抗IL-24单克隆抗体可通过抑制PI3K/AKT通路，增强黑色素瘤细胞对放疗的敏感性，提示其作为放疗增敏剂的潜力。
2. **"Therapeutic targeting of IL-24 via monoclonal antibody suppresses tumor growth in colorectal cancer models"**
*作者：Chen L, et al.*
摘要：开发了一种靶向IL-24的人源化抗体，在结直肠癌小鼠模型中显著抑制肿瘤生长并诱导肿瘤细胞凋亡，机制与抑制STAT3信号相关。
3. **"IL-24-neutralizing antibody ameliorates autoimmune inflammation in rheumatoid arthritis"**
*作者：Wang Y, et al.*
摘要：研究发现IL-24在类风湿关节炎患者滑膜中高表达，使用中和抗体可减少促炎细胞因子释放，缓解小鼠模型中的关节炎症。
4. **"Dual-targeting IL-24 and PD-1 antibodies synergize in enhancing antitumor immunity"**
*作者：Kim H, et al.*
摘要：联合使用IL-24抗体与PD-1抑制剂，通过激活CD8+ T细胞和抑制调节性T细胞，显著提升抗肿瘤免疫应答，优于单一疗法。
(注：以上文献为示例，实际研究请通过PubMed或学术数据库检索确认。)
**Background of IL-24 Antibodies**
Interleukin-24 (IL-24), a member of the IL-10 cytokine family, is a multifunctional protein with roles in immune regulation, inflammation, and tumor suppression. Initially identified as melanoma differentiation-associated antigen-7 (MDA-7), IL-24 is produced by immune cells (e.g., monocytes, T cells) and epithelial tissues. It signals through two heterodimeric receptor complexes: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. activating JAK/STAT, MAPK, and PI3K/AKT pathways. Notably, IL-24 induces selective apoptosis in cancer cells while sparing normal cells, making it a promising therapeutic target.
IL-24 antibodies are tools for detecting IL-24 expression or modulating its activity. Monoclonal antibodies (mAbs) and polyclonal antibodies are used in research to study IL-24's role in diseases like cancer, autoimmune disorders, and infections. For example, anti-IL-24 mAbs help quantify IL-24 levels in tissues or serum via ELISA, Western blot, or immunohistochemistry, aiding in biomarker discovery. In therapeutic contexts, neutralizing antibodies may block IL-24's pro-inflammatory effects in autoimmune conditions, while agonist antibodies could enhance its anti-tumor activity.
Recent studies highlight IL-24's dual role—promoting apoptosis in tumors yet contributing to inflammatory pathologies. Antibodies targeting IL-24 thus hold potential for precision medicine, particularly in oncology. Challenges remain in optimizing specificity and delivery, but ongoing research underscores IL-24 antibodies as valuable for both mechanistic studies and clinical applications.
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