| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UK; UMPK; TSA903 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human UCK2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UCK2抗体的模拟参考文献示例(仅供格式参考，具体文献需通过学术数据库查询)：
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1. **文献名称**: *Development and Characterization of a Monoclonal Antibody Specific for Human UCK2*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对人UCK2蛋白的高特异性单克隆抗体，并通过Western blot和免疫组化验证其反应性。该抗体成功用于检测多种癌细胞系中UCK2的蛋白表达水平，为研究UCK2在肿瘤代谢中的作用提供了工具。
2. **文献名称**: *UCK2 Expression in Colorectal Cancer: Correlation with Chemotherapy Resistance*
**作者**: Zhang L, et al.
**摘要**: 通过免疫组织化学分析发现，UCK2在结直肠癌组织中高表达，且与5-氟尿嘧啶(5-FU)耐药性显著相关。研究提示UCK2可能作为预测化疗疗效的生物标志物。
3. **文献名称**: *The Role of UCK2 in Mitochondrial RNA Modification and Cellular Proliferation*
**作者**: Tanaka K, et al.
**摘要**: 利用UCK2特异性抗体进行蛋白质定位研究，发现UCK2定位于线粒体，并参与调控线粒体RNA修饰。敲低UCK2显著抑制癌细胞增殖，表明其在线粒体功能中的关键作用。
4. **文献名称**: *UCK2 as a Novel Target in Pancreatic Cancer: Antibody-Based Therapeutic Potential*
**作者**: Chen R, et al.
**摘要**: 研究验证了UCK2抗体在胰腺癌模型中的治疗潜力。通过阻断UCK2活性，可抑制肿瘤生长并增强吉西他滨的疗效，提示其作为联合治疗靶点的可能性。
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**备注**：以上文献名为示例，实际文献请通过 **PubMed**、**Google Scholar** 等平台检索关键词(如“UCK2 antibody”、“UCK2 cancer”)获取。建议结合最新研究以反映领域进展。
UCK2 (uridine-cytidine kinase 2) is a key enzyme in the pyrimidine salvage pathway, responsible for phosphorylating uridine and cytidine to form their respective monophosphates, a critical step in nucleotide synthesis and RNA metabolism. It plays a regulatory role in maintaining cellular nucleotide pools and is implicated in the activation of anticancer prodrugs like gemcitabine. Dysregulation of UCK2 has been linked to various cancers, including hepatocellular carcinoma, colorectal cancer, and leukemia, where its overexpression often correlates with tumor progression, poor prognosis, and chemoresistance.
UCK2 antibodies are essential tools for studying the expression, localization, and function of this enzyme in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to quantify UCK2 levels in tissues or cell lines, assess its subcellular distribution, and explore its role in cancer biology. Research using UCK2 antibodies has highlighted its potential as a biomarker for cancer diagnosis and as a therapeutic target. For instance, inhibiting UCK2 activity may sensitize cancer cells to chemotherapy. Additionally, studies suggest UCK2 is transcriptionally regulated by p53. linking it to stress response pathways. These antibodies thus contribute to understanding nucleotide metabolism in disease and developing targeted therapies.
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