Rabbit Polyclonal UBN2 Antibody

UBN2 (Ubinuclein 2) is a nuclear protein implicated in chromatin remodeling and transcriptional regulation. It interacts with the HIRA histone chaperone complex, which facilitates the deposition of the histone variant H3.3 into chromatin, a process critical for gene expression, DNA repair, and epigenetic inheritance. UBN2 contains conserved domains, including a Hpc2-related domain, enabling its role in chromatin binding and complex assembly. Studies suggest UBN2 is involved in cellular senescence, cell cycle progression, and embryonic development. Antibodies targeting UBN2 are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study UBN2's function in chromatin dynamics and disease contexts. Dysregulation of UBN2 has been linked to cancers and developmental disorders, highlighting its biomedical relevance. These antibodies are typically validated for specificity in model organisms (e.g., humans, mice) and are available as monoclonal or polyclonal variants from commercial suppliers. Ongoing research aims to elucidate UBN2's precise mechanisms in histone deposition, its interplay with other chromatin remodelers, and its potential as a therapeutic target.