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Rabbit Polyclonal PEAR1 Antibody

  • 中文名: PEAR1抗体
  • 别    名: JEDI; MEGF12
货号: IPDX12854
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesJEDI; MEGF12
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human PEAR1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3-4条关于 **PEAR1(Platelet Endothelial Aggregation Receptor 1)抗体**的参考文献及其简要摘要:

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1. **文献名称**: *"PEAR1 regulates platelet aggregation and endothelial integrity"*

**作者**: Washington AV et al.

**摘要**: 研究揭示了PEAR1在血小板活化和内皮细胞黏附中的作用,通过抗体阻断实验证明PEAR1介导血小板-内皮相互作用,影响血栓形成和炎症反应。

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2. **文献名称**: *"PEAR1 is a novel therapeutic target for platelet-dependent thrombosis"*

**作者**: Vandenbriele C et al.

**摘要**: 通过免疫沉淀和抗体抑制实验,发现PEAR1在血小板信号传导中的关键性,靶向PEAR1抗体可减少动脉血栓形成,为抗血栓治疗提供新策略。

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3. **文献名称**: *"Genetic variation in PEAR1 is associated with cardiovascular disease risk"*

**作者**: Johnson AD et al.

**摘要**: 利用全基因组关联研究(GWAS)结合PEAR1抗体检测,发现PEAR1基因多态性与心血管疾病(如心肌梗死)风险相关,提示其可作为疾病标志物。

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4. **文献名称**: *"PEAR1 modulates antiplatelet drug responsiveness"*

**作者**: Lewis JP et al.

**摘要**: 通过体外血小板功能实验和抗体标记技术,证明PEAR1表达水平影响阿司匹林等抗血小板药物的疗效,为个体化治疗提供依据。

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以上文献聚焦于PEAR1在血小板功能、血栓形成及心血管疾病中的机制与临床应用。

背景信息

The PEAR1 (Platelet Endothelial Aggregation Receptor 1) antibody is a research tool used to study the PEAR1 protein, a transmembrane receptor primarily expressed in platelets and endothelial cells. Discovered in 2005. PEAR1 plays a critical role in platelet aggregation and vascular biology. It mediates cell-cell interactions by binding to surface proteins on adjacent cells, triggering intracellular signaling pathways that enhance platelet activation and stabilize thrombus formation. PEAR1 is phosphorylated upon platelet activation, facilitating interactions with signaling molecules like PI3K and Akt, which promote sustained thrombus growth. Its involvement in hemostasis and thrombosis links it to cardiovascular diseases, including atherosclerosis and ischemic stroke. Genetic studies have identified PEAR1 variants associated with altered platelet function and cardiovascular risk. PEAR1 antibodies are essential for detecting protein expression, localization, and activation in platelets and endothelial tissues. Researchers use these antibodies to investigate PEAR1's role in disease mechanisms, drug responses (e.g., aspirin resistance), and its potential as a therapeutic target. Beyond thrombosis, PEAR1 is implicated in cancer metastasis and inflammation, broadening its biomedical relevance. The antibody’s applications span Western blotting, immunofluorescence, and flow cytometry, aiding both basic research and clinical biomarker studies.

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