Rabbit Polyclonal HTRA2 Antibody

The HTRA2 (HtrA serine peptidase 2) antibody is a tool used to study the HTRA2 protein, a mitochondrial serine protease involved in cellular homeostasis and apoptosis. HTRA2. also known as Omi, plays dual roles: it regulates protein quality control by degrading misfolded proteins under stress and promotes apoptosis by cleaving inhibitor of apoptosis proteins (IAPs) upon mitochondrial outer membrane permeabilization. Mutations in the HTRA2 gene are linked to neurodegenerative disorders, particularly Parkinson’s disease, as impaired HTRA2 activity leads to mitochondrial dysfunction and neuronal death. Researchers employ HTRA2 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression, localization, and interactions in disease models. These studies aim to clarify HTRA2's role in pathologies, including neurodegeneration, cancer, and ischemic injury, where dysregulated proteostasis or apoptosis pathways are implicated. Recent work also explores HTRA2’s potential as a therapeutic target, with antibodies aiding in validating its activity or inhibition in preclinical studies. Overall, HTRA2 antibodies are vital for unraveling the protein’s complex functions in health and disease.