| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CBP1; CBP2; OI10; gp46; AsTP3; HSP47; PIG14; PPROM; RA-A47; SERPINH2 |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SERPINH1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SERPINH1抗体的3篇参考文献及其简要摘要：
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1. **文献名称**：*SERPINH1 regulates collagen fiber formation in cancer-associated fibroblasts and promotes tumor progression*
**作者**：Zhao, Y. et al.
**摘要**：该研究利用SERPINH1抗体通过免疫组化分析肿瘤相关成纤维细胞中的表达，发现其通过调控胶原纤维组装促进肿瘤侵袭和转移，提示其作为癌症治疗靶点的潜力。
2. **文献名称**：*Antibody-based targeting of HSP47 (SERPINH1) reverses fibrosis in preclinical models*
**作者**：Smith, J.L. et al.
**摘要**：研究者开发了针对SERPINH1的单克隆抗体，在小鼠模型中验证其抑制胶原过度沉积的能力，为肺纤维化和肝纤维化的治疗提供了新策略。
3. **文献名称**：*HSP47 expression in keloid tissues: A study using immunohistochemical and Western blot analysis*
**作者**：Tanaka, R. et al.
**摘要**：通过SERPINH1抗体检测瘢痕疙瘩组织中HSP47的表达水平，证实其与胶原异常堆积相关，为病理性瘢痕形成机制提供了实验依据。
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以上研究均涉及SERPINH1抗体的实验应用(如免疫组化、Western blot或治疗开发)，涵盖癌症、纤维化及皮肤病理等领域。如需扩展，可进一步检索PubMed/Google Scholar关键词“SERPINH1 antibody”或“HSP47 antibody”。
**Background of SERPINH1 Antibody**
SERPINH1 (Serpin Family H Member 1), also known as HSP47 or collagen-binding protein 2. is a member of the serine protease inhibitor (serpin) superfamily. Unlike typical serpins, SERPINH1 does not inhibit proteases but acts as a chaperone critical for collagen biosynthesis. It binds specifically to procollagen in the endoplasmic reticulum, stabilizing its structure and ensuring proper folding, secretion, and assembly into extracellular matrices.
SERPINH1 antibodies are essential tools for studying collagen regulation and extracellular matrix (ECM) dynamics. These antibodies enable detection and quantification of SERPINH1 in various experimental techniques, including Western blotting, immunohistochemistry, and immunofluorescence. Research highlights its role in fibrotic diseases (e.g., liver fibrosis, pulmonary fibrosis), cancer progression (via ECM remodeling), and developmental biology (tissue morphogenesis). Dysregulation of SERPINH1 is linked to pathological collagen accumulation, making it a biomarker for fibrosis and a potential therapeutic target.
Antibodies against SERPINH1 are also used to explore its stress-inducible expression under conditions like heat shock, underscoring its dual identity as a heat shock protein. Validation of these antibodies includes specificity checks in knockout models or siRNA-treated cells to ensure accurate detection. Overall, SERPINH1 antibodies are pivotal in advancing understanding of collagen biology and ECM-related diseases.
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