| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TRIB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于TRIB1抗体的参考文献及其摘要概括：
1. **《TRIB1 regulates macrophage polarization and susceptibility to experimental autoimmune encephalomyelitis》**
- 作者：Yamamoto R, et al.
- 摘要：该研究利用TRIB1特异性抗体，通过Western blot和免疫组化证实TRIB1在巨噬细胞极化中的关键作用，发现其缺失会加剧小鼠实验性自身免疫性脑脊髓炎(EAE)症状。
2. **《TRIB1 modulates leukemogenesis through C/EBPα regulation in acute myeloid leukemia》**
- 作者：Zhao Y, et al.
- 摘要：研究通过免疫沉淀和抗体阻断实验，揭示TRIB1与转录因子C/EBPα的相互作用促进急性髓系白血病(AML)进展，为靶向TRIB1的抗体治疗提供理论依据。
3. **《TRIB1 functions as a prognostic biomarker and immune infiltration regulator in hepatocellular carcinoma》**
- 作者：Wang L, et al.
- 摘要：通过免疫组织化学分析TRIB1抗体标记的组织样本，发现TRIB1高表达与肝癌患者不良预后相关，并可能通过调控肿瘤微环境中的免疫细胞浸润影响病程。
4. **《Antibody-based targeting of TRIB1 disrupts lipid metabolism and inhibits diet-induced obesity》**
- 作者：Kawakami A, et al.
- 摘要：开发了一种靶向TRIB1的单克隆抗体，证实其可通过抑制肝脏脂质合成通路改善小鼠饮食诱导的肥胖，为代谢性疾病治疗提供新策略。
(注：以上文献为模拟示例，实际引用需核对真实数据库。)
The TRIB1 (Tribbles Pseudokinase 1) antibody is a crucial tool for studying the TRIB1 protein, a member of the Tribbles family of pseudokinases involved in regulating cellular processes such as proliferation, differentiation, and apoptosis. TRIB1 acts as a scaffold protein, modulating signaling pathways like MAPK/ERK and PI3K/AKT by interacting with kinases (e.g., MEK1) and transcription factors (e.g., C/EBPα). Its role in ubiquitin-mediated protein degradation, particularly through binding E3 ligases like COP1. links it to metabolic regulation, inflammation, and cancer. Dysregulation of TRIB1 is implicated in diseases such as acute myeloid leukemia, atherosclerosis, and lipid metabolism disorders.
TRIB1 antibodies enable detection and functional analysis in techniques including Western blotting, immunofluorescence, and immunohistochemistry. They are vital for exploring tissue-specific expression, protein-protein interactions, and post-translational modifications. Researchers also use these antibodies to study TRIB1's dual roles in oncogenesis—acting as tumor suppressor or promoter depending on cellular context. Validated antibodies with specificity confirmed via knockout controls are essential, given TRIB1's structural homology with other Tribbles family members (TRIB2. TRIB3). Overall, TRIB1 antibodies are pivotal for unraveling its complex regulatory networks and therapeutic potential in human diseases.
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