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Recombinant Human PLAC8 protein

  • 中文名: 胎盘特异基因8蛋白(PLAC8)重组蛋白
  • 别    名: PLAC8;Placenta-specific gene 8 protein
货号: PA1000-2412
Price: ¥询价
数量:
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产品详情

纯度>85%SDS-PAGE.
种属Human
靶点PLAC8
Uniprot NoQ9NZF1
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-115aa
氨基酸序列MGSSHHHHHH SSGLVPRGSH MGSMQAQAPV VVVTQPGVGP GPAPQNSNWQ TGMCDCFSDC GVCLCGTFCF PCLGCQVAAD MNECCLCGTS VAMRTLYRTR YGIPGSICDD YMATLCCPHC TLCQIKRDIN RRRAMRTF
预测分子量15 kDa
蛋白标签His tag N-Terminus
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于PLAC8重组蛋白的参考文献示例(注:以下文献为虚拟示例,实际文献需通过学术数据库检索确认):

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1. **标题**:*Recombinant PLAC8 Protein Enhances Cell Proliferation in Colorectal Cancer via Wnt/β-Catenin Signaling*

**作者**:Smith A, et al.

**摘要**:研究通过重组PLAC8蛋白处理结直肠癌细胞,发现其激活Wnt/β-catenin通路,促进癌细胞增殖和迁移,提示PLAC8在肿瘤进展中的作用。

2. **标题**:*Expression and Functional Analysis of PLAC8 Recombinant Protein in Macrophage Polarization*

**作者**:Zhang Y, et al.

**摘要**:利用大肠杆菌表达系统成功纯化重组PLAC8蛋白,并证明其通过调控STAT3通路诱导M2型巨噬细胞极化,影响免疫微环境。

3. **标题**:*PLAC8 Recombinant Protein Attenuates Renal Fibrosis in Diabetic Nephropathy Models*

**作者**:Kim S, et al.

**摘要**:在糖尿病肾病小鼠模型中,重组PLAC8蛋白通过抑制TGF-β/Smad信号通路减少肾纤维化,表明其潜在治疗应用。

4. **标题**:*Structural Characterization of PLAC8 and Its Role in Autophagy Regulation*

**作者**:Garcia R, et al.

**摘要**:解析重组PLAC8蛋白的晶体结构,并揭示其通过结合Beclin-1调控自噬过程,影响细胞应激反应。

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**建议**:实际研究中,可通过PubMed、Web of Science等平台检索关键词“PLAC8 recombinant protein”或“PLAC8 expression”,筛选近5年高被引文献获取权威信息。

背景信息

PLAC8 (Placenta-specific 8), also known as Onzin, is a multifunctional protein encoded by the *PLAC8* gene. Initially identified for its placental expression during murine development, it is now recognized as a conserved protein across vertebrates, with roles in diverse physiological and pathological processes. Structurally, PLAC8 contains a cysteine-rich domain, suggesting potential involvement in protein-protein interactions or redox regulation. Its expression isn’t limited to reproductive tissues; it is detected in immune cells, epithelial tissues, and organs like the liver and pancreas.

Functionally, PLAC8 is implicated in cell proliferation, differentiation, and apoptosis. It modulates immune responses by influencing macrophage polarization and cytokine production, linking it to inflammatory diseases. In cancer, PLAC8 exhibits dual roles—acting as either an oncogene or tumor suppressor depending on context. For instance, it promotes growth in colorectal and liver cancers but inhibits progression in pancreatic and lung cancers. It also regulates metabolic pathways, including insulin secretion and lipid metabolism, associating it with diabetes and obesity.

Recombinant PLAC8 protein is engineered via bacterial or mammalian expression systems, enabling studies on its molecular mechanisms. Researchers use it to map binding partners, analyze structural motifs, and explore therapeutic potential. For example, recombinant PLAC8 has been utilized to investigate its role in enhancing β-cell function or blocking tumorigenic signaling. However, challenges remain in understanding its precise signaling pathways and tissue-specific effects. Current research focuses on harnessing PLAC8’s regulatory properties for targeted therapies, biomarker development, and regenerative medicine, underscoring its growing relevance in translational medicine.

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