| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/150-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UBC3B; CDC34B; E2-CDC34B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human UBE2R2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBE2R2抗体的示例参考文献(内容为虚构示例，仅供参考)：
1. **文献名称**: "UBE2R2 regulates cell cycle progression via APC/C-mediated ubiquitination"
**作者**: Zhang L, et al.
**摘要**: 本研究通过UBE2R2特异性抗体揭示了其在调控APC/C复合体介导的Cyclin B1泛素化降解中的作用，发现UBE2R2缺失导致细胞周期G2/M期阻滞，提示其作为癌症治疗靶点的潜力。
2. **文献名称**: "Development of a high-specificity monoclonal antibody for UBE2R2 in tumor profiling"
**作者**: Wang Y, et al.
**摘要**: 文章报道了一种新型UBE2R2单克隆抗体的开发与验证，通过免疫印迹和免疫荧光证实其在结直肠癌组织中的高表达，并与患者预后不良相关。
3. **文献名称**: "UBE2R2 genetic variants and antibody-based detection in neurodegenerative disorders"
**作者**: Smith J, et al.
**摘要**: 利用UBE2R2抗体分析阿尔茨海默病患者脑组织样本，发现UBE2R2异常聚集与tau蛋白过度磷酸化相关，提示其参与神经退行性病变的分子机制。
4. **文献名称**: "Comparative analysis of UBE2R2 antibody performance in proteomic studies"
**作者**: Chen H, et al.
**摘要**: 系统性比较了市售UBE2R2抗体的特异性与灵敏度，指出某些抗体存在交叉反应问题，并推荐了优化实验条件以提高检测可靠性。
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**备注**：以上文献为模拟示例，实际文献需通过PubMed、Web of Science等数据库检索(可使用关键词：UBE2R2 antibody, UBE2R2 function, UBE2R2 disease association)。
The UBE2R2 antibody is a research tool targeting the ubiquitin-conjugating enzyme E2 R2 (UBE2R2), a key component of the ubiquitin-proteasome system involved in protein degradation. UBE2R2. also known as CDC34B, belongs to the E2 enzyme family responsible for transferring ubiquitin to substrate proteins, often in collaboration with E3 ligases. This post-translational modification regulates diverse cellular processes, including cell cycle progression, DNA repair, and apoptosis. UBE2R2 specifically interacts with SCF (Skp1-Cul1-F-box) E3 ligase complexes, facilitating the ubiquitination of substrates like cyclin-dependent kinase inhibitors.
Antibodies against UBE2R2 are widely used in molecular biology to study its expression, localization, and function. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunoprecipitation. Research has linked UBE2R2 dysregulation to several diseases, particularly cancers, where altered ubiquitination pathways contribute to tumorigenesis. For instance, UBE2R2 overexpression has been observed in certain malignancies, potentially driving uncontrolled cell proliferation.
The antibody's specificity is critical due to structural similarities between UBE2R2 and its paralog UBE2R1 (CDC34A). Some isoforms or splice variants (e.g., UBE2R2-1 and UBE2R2-2) may require validation of antibody cross-reactivity. Ongoing studies explore UBE2R2's role in therapeutic contexts, including its potential as a biomarker or drug target in precision oncology.
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