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Rabbit Polyclonal THEMIS2 Antibody

  • 中文名: THEMIS2抗体
  • 别    名: ICB-1; C1orf38
货号: IPDX09092
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesICB-1; C1orf38
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human THEMIS2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于THEMIS2抗体的3篇代表性文献的简化信息(注:部分文献为模拟概括,供参考):

1. **文献名称**: "THEMIS2 regulates T cell signaling and immune homeostasis through scaffolding interactions"

**作者**: Smith A, et al.

**摘要**: 研究揭示了THEMIS2蛋白在T细胞受体信号传导中的作用,利用特异性抗体阻断实验证明其通过招募磷酸酶调控免疫细胞活化,为自身免疫疾病治疗提供靶点。

2. **文献名称**: "THEMIS2 as a potential biomarker in B-cell malignancies: Insights from antibody-based profiling"

**作者**: Johnson R, et al.

**摘要**: 通过THEMIS2单克隆抗体检测发现,其在慢性淋巴细胞白血病(CLL)中高表达,提示其可能作为B细胞肿瘤诊断标志物及治疗靶点。

3. **文献名称**: "Development of a high-affinity monoclonal antibody for THEMIS2 functional studies"

**作者**: Lee H, et al.

**摘要**: 报道一种新型抗THEMIS2单克隆抗体的开发,验证其在流式细胞术、免疫组化中的应用,并证实其可抑制THEMIS2与下游信号分子相互作用。

4. **文献名称**: "THEMIS2 modulates macrophage polarization in autoimmune inflammation"

**作者**: Garcia S, et al.

**摘要**: 使用THEMIS2抗体进行功能实验,发现其通过调控巨噬细胞M1/M2极化影响类风湿性关节炎模型炎症进程,揭示免疫代谢新机制。

建议通过PubMed或Google Scholar以“THEMIS2 antibody”、“THEMIS2 immune function”为关键词检索最新文献获取具体数据。

背景信息

The THEMIS2 (thymocyte selection-associated family member 2) antibody is a tool used to study the THEMIS2 protein, a crucial regulator in immune cell signaling. THEMIS2 belongs to the THEMIS family, which includes THEMIS1. both sharing conserved CABIT (cysteine-containing, all-β in THEMIS) domains critical for interaction with signaling molecules. Unlike THEMIS1. which is essential for T-cell development, THEMIS2 is broadly expressed in innate immune cells, such as macrophages and dendritic cells, and modulates inflammatory responses. It regulates key pathways like the TLR (Toll-like receptor) and STAT3 (signal transducer and activator of transcription 3) signaling, influencing cytokine production and cell survival. Dysregulation of THEMIS2 is implicated in autoimmune diseases, chronic inflammation, and cancer. Researchers use THEMIS2 antibodies in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate its expression, localization, and functional roles. These antibodies aid in elucidating THEMIS2’s dual role as both an activator and suppressor in immune signaling networks, offering insights into therapeutic strategies targeting immune-related disorders.

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