关键信息
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基因名
GSPT1
- 应用
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别名
GSPT1; ERF3AEukaryotic peptide chain release factor GTP-binding subunit ERF3A; Eukaryotic peptide chain release factor subunit 3a; eRF3a; G1 to S phase transition protein 1 homolog
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种属
Human
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表达系统
Yeast
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P15170
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表达区间
1-499aa
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分子量
59.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GSPT1 (G1 to S Phase Transition 1) is a protein associated with various cellular processes, including translation termination and cell cycle regulation. It plays a crucial role in maintaining the stability of mRNA and facilitating its translation by interacting with the ribosome and other cellular factors. Research has shown that GSPT1 is involved in the regulation of gene expression and has implications in cancer biology, as its overexpression is often linked to tumorigenesis and poor prognosis in several cancers. Furthermore, GSPT1 has been identified as a potential target for therapeutic strategies aimed at modulating protein synthesis in cancer cells. The recombinant expression of GSPT1 in various host systems enables a detailed investigation of its biochemical properties and interactions, providing insights into its functional mechanisms and roles in different cellular contexts. Understanding the structure and function of GSPT1 through recombinant protein studies could pave the way for the development of novel anticancer therapies and contribute to our overall understanding of cellular regulation and homeostasis.
