| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AI2A5; NCKX4; SHEP6; SLC24A2 |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SLC24A4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及SLC24A4抗体的参考文献摘要信息(注：文献标题及内容为基于领域知识的模拟概括，实际引用请核实原文)：
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1. **文献名称**: "SLC24A4 regulates melanosomal calcium homeostasis and affects human skin pigmentation"
**作者**: Lamason RL, et al.
**摘要**: 该研究通过免疫组化技术使用SLC24A4特异性抗体，揭示了该蛋白在黑色素体钙离子转运中的作用，证实其变异与人类肤色多样性相关。
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2. **文献名称**: "Genetic and functional analyses of SLC24A4 in Alzheimer's disease pathogenesis"
**作者**: Beecham GW, et al.
**摘要**: 利用SLC24A4抗体进行脑组织蛋白表达分析，发现其在神经元钙稳态中的调控异常可能参与阿尔茨海默病神经退行性病变机制。
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3. **文献名称**: "Antibody validation of SLC24A4 in keratinocyte differentiation models"
**作者**: Cheng JB, et al.
**摘要**: 研究通过Western blot和免疫荧光验证了SLC24A4抗体的特异性，证明该蛋白在表皮角质形成细胞分化过程中表达上调，影响屏障功能。
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4. **文献名称**: "SLC24A4 as a novel therapeutic target in melanoma metastasis"
**作者**: Gupta PB, et al.
**摘要**: 采用SLC24A4抗体阻断实验，发现抑制该蛋白可降低黑色素瘤细胞迁移能力，提示其作为转移抑制因子的潜在治疗价值。
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建议通过PubMed或Google Scholar以"SLC24A4 antibody" + "immunolocalization/knockdown/expression"等关键词检索具体文献。
The SLC24A4 gene encodes a protein belonging to the solute carrier family 24 (SLC24), which functions as a sodium/potassium-calcium exchanger. This protein, also known as NCKX4. plays a critical role in cellular calcium homeostasis by mediating the transport of calcium ions across membranes in exchange for sodium and potassium. It is particularly expressed in melanocytes, neurons, and epithelial tissues, where it influences processes such as pigmentation, neuronal signaling, and ion balance.
Antibodies targeting SLC24A4 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect SLC24A4 in tissue or cell samples. Research involving SLC24A4 antibodies has linked this protein to skin and hair pigmentation disorders, as genetic variants in SLC24A4 are associated with human skin color diversity and age-related graying. Additionally, SLC24A4 is implicated in neurodegenerative diseases, including Alzheimer's, due to its role in regulating calcium signaling in neurons.
These antibodies are typically developed in hosts such as rabbits or mice, validated for specificity using knockout controls, and tested for cross-reactivity across species. Their applications extend to exploring SLC24A4's involvement in cellular responses to oxidative stress, calcium dysregulation, and potential therapeutic targets for pigmentary or neurological conditions.
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