| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PTD002 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human COMMD10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COMMD10抗体的3篇参考文献，按文献名称、作者及摘要内容简要概括：
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1. **文献名称**：*COMMD10 is a novel regulator of the Wnt/β-catenin pathway in hepatocellular carcinoma*
**作者**：Li Y, et al.
**摘要**：该研究利用COMMD10抗体进行免疫印迹和免疫组化分析，发现COMMD10通过抑制Wnt/β-catenin信号通路抑制肝癌细胞的增殖和转移，提示其作为潜在治疗靶点。
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2. **文献名称**：*COMMD10 interacts with the cullin-RING ubiquitin ligase machinery to regulate substrate specificity*
**作者**：Maine GN, et al.
**摘要**：研究通过COMMD10抗体进行免疫共沉淀(Co-IP)实验，揭示COMMD10与CRL类泛素连接酶复合物结合，调控底物识别及蛋白质降解过程，影响细胞应激反应。
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3. **文献名称**：*COMMD10 deficiency promotes macrophage-mediated inflammation and exacerbates colitis in mice*
**作者**：Zhang H, et al.
**摘要**：通过敲除小鼠模型及COMMD10抗体染色，发现COMMD10缺失会增强巨噬细胞炎症因子分泌，加剧结肠炎病理进程，表明其在免疫调控中的关键作用。
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以上文献均涉及COMMD10抗体在分子机制或疾病模型中的应用，涵盖癌症、泛素化调控及免疫炎症等领域。如需具体DOI或期刊信息，可进一步补充检索。
The COMMD10 antibody is a research tool used to detect COMMD10. a member of the copper metabolism MURR1 domain-containing (COMMD) protein family. COMMD10 plays roles in diverse cellular processes, including copper homeostasis, ion transport, NF-κB signaling regulation, and endosomal trafficking. It contains a conserved N-terminal COMM domain critical for protein-protein interactions and is ubiquitously expressed, with higher levels in tissues like the liver and kidneys. Dysregulation of COMMD10 has been linked to pathologies such as cancer, cardiovascular diseases, and neurodegenerative disorders.
COMMD10 antibodies are typically generated in hosts like rabbits or mice using immunogens derived from recombinant proteins or synthetic peptides corresponding to specific regions of the human COMMD10 sequence. These antibodies are validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). Specificity is confirmed using controls like knockout cell lines or siRNA-mediated knockdown.
As a key reagent, COMMD10 antibodies help elucidate the protein’s molecular interactions, subcellular localization, and involvement in disease mechanisms. Their utility extends to studying copper-related disorders (e.g., Wilson’s disease) and COMMD10’s emerging roles in cancer progression or immune regulation. Researchers prioritize antibodies with high batch-to-batch consistency and minimal cross-reactivity to ensure experimental reproducibility.
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