| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GMF |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GMFB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于GMFB抗体的相关文献信息(注：文献为虚构示例，实际研究需通过学术数据库检索确认)：
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1. **文献名称**: *GMFB Antibody Attenuates Neuroinflammation in a Mouse Model of Multiple Sclerosis*
**作者**: Smith A, et al.
**摘要**: 研究通过注射GMFB抗体抑制胶质细胞成熟因子β(GMFB)活性，发现其可显著减少中枢神经系统炎症反应，并缓解实验性自身免疫性脑脊髓炎(EAE)模型小鼠的神经功能损伤，提示GMFB抗体在治疗多发性硬化症中的潜在价值。
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2. **文献名称**: *GMFB as a Biomarker in Alzheimer's Disease: Insights from Immunohistochemical Analysis*
**作者**: Chen L, et al.
**摘要**: 利用特异性GMFB抗体进行脑组织染色，发现阿尔茨海默病患者大脑中GMFB蛋白表达水平显著升高，且与β-淀粉样斑块沉积和神经炎症程度呈正相关，表明GMFB可能作为神经退行性疾病的生物标志物。
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3. **文献名称**: *Targeting GMFB with Neutralizing Antibodies Reduces Post-Stroke Neuronal Apoptosis*
**作者**: Tanaka K, et al.
**摘要**: 在缺血性脑卒中模型中，使用GMFB中和抗体阻断其信号通路，可抑制小胶质细胞过度活化，减少神经元凋亡并促进功能恢复，为卒中后神经保护提供了新策略。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“GMFB antibody”、“Glia Maturation Factor Beta therapeutic”等获取最新研究。
GMFB (glia maturation factor beta) is a conserved 17 kDa protein first identified in the 1970s for its role in glial cell differentiation and neurodevelopment. It belongs to the GMF family, sharing structural homology with GMFG (gamma isoform). Primarily expressed in the central nervous system, GMFB localizes in astrocytes, microglia, and some neurons. Functionally, it acts as an intracellular signaling modulator, interacting with proteins like ARPC2 (actin-related protein 2/3 complex) to regulate cytoskeletal dynamics and inflammatory responses.
Research highlights GMFB's dual role in neuroprotection and neurodegeneration. It promotes neurite outgrowth under physiological conditions but becomes pathogenic when overexpressed during neuroinflammation. Elevated GMFB levels correlate with Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it exacerbates glial activation, oxidative stress, and cytokine release (e.g., IL-1β, TNF-α). This pro-inflammatory activity links GMFB to blood-brain barrier disruption and neuronal apoptosis.
GMFB antibodies, developed as research tools, enable protein detection in immunoassays (Western blot, IHC/IF) and functional studies. Neutralizing antibodies are being explored to inhibit GMFB's pathological effects in preclinical models. Recent investigations also suggest extracellular GMFB secretion during cellular stress, expanding its potential as a therapeutic target and biomarker for neurological disorders. Current challenges include understanding isoform-specific functions and tissue-dependent signaling pathways.
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