| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CED12; CED-12; ELMO-1 |
| WB Predicted band size | 84 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ELMO1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ELMO1抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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**1. 文献名称**：*ELMO1 interacts with Dock180 to promote Rac activation and cell migration in response to phagocytosis*
**作者**：K. Gumienny et al.
**摘要**：该研究通过免疫共沉淀和Western blot技术，利用ELMO1特异性抗体揭示了ELMO1与Dock180蛋白的相互作用机制，证明两者协同激活Rac1 GTP酶，调控吞噬作用中的细胞迁移。研究强调了ELMO1抗体在检测复合物形成中的关键作用。
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**2. 文献名称**：*ELMO1 expression correlates with invasive potential in colorectal cancer*
**作者**：S. Watanabe et al.
**摘要**：作者使用ELMO1抗体对结直肠癌组织进行免疫组化分析，发现ELMO1高表达与肿瘤侵袭性和转移相关。实验通过敲低ELMO1并配合抗体验证，表明其通过Rac1通路增强癌细胞迁移，提示ELMO1作为潜在治疗靶点。
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**3. 文献名称**：*Genetic ablation of ELMO1 attenuates hyperglycemia-induced renal inflammation*
**作者**：M. Leak et al.
**摘要**：研究通过ELMO1敲除小鼠模型及ELMO1抗体检测，发现ELMO1缺失可减轻高血糖诱导的肾脏炎症反应。抗体用于Western blot和免疫荧光，证实ELMO1在糖尿病肾病中调控炎症细胞浸润的作用。
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这些文献展示了ELMO1抗体在分子机制、癌症及疾病模型研究中的关键应用。如需具体文章，可进一步通过PubMed或ResearchGate检索标题获取全文。
ELMO1 (Engulfment and Cell Motility Protein 1) is a cytoplasmic protein that plays a critical role in regulating cytoskeletal reorganization, cell migration, and phagocytosis. It functions as a key adaptor molecule in the Rac GTPase signaling pathway by interacting with Dock180 (Dedicator of Cytokinesis 1), forming the ELMO-Dock180 complex. This complex activates Rac1. promoting actin polymerization and membrane remodeling essential for processes like immune cell trafficking, neuronal development, and clearance of apoptotic cells. Dysregulation of ELMO1 is implicated in cancer metastasis, inflammatory diseases, and developmental disorders.
ELMO1 antibodies are essential tools for studying its expression, localization, and interactions in various biological contexts. Researchers use these antibodies in techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation to explore ELMO1’s role in tumor microenvironment modulation, macrophage function, and epithelial-mesenchymal transition (EMT) in cancer. In clinical research, ELMO1 is investigated as a potential biomarker for diseases like diabetic nephropathy and colorectal cancer. Its involvement in PI3K/Akt and Wnt signaling pathways further highlights its therapeutic relevance. Antibodies targeting ELMO1 enable mechanistic insights into pathological processes and support drug discovery efforts aimed at modulating Rac-dependent cellular behaviors.
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