Recombinant Mouse C1qtnf6 protein

C1qtnf6 (C1q and tumor necrosis factor-related protein 6), also known as CTRP6. is a member of the CTRP family, a group of secreted proteins structurally related to adiponectin. These proteins are characterized by a conserved C-terminal C1q domain and a variable N-terminal collagen-like domain, which facilitates oligomerization and interaction with extracellular components. CTRP6 is primarily expressed in adipose tissue, liver, and immune cells, suggesting roles in metabolic regulation and immune response.

Functionally, CTRP6 has been implicated in modulating glucose and lipid metabolism, inflammation, and cell differentiation. Studies highlight its dual role in metabolic homeostasis: it enhances insulin sensitivity in peripheral tissues while suppressing hepatic glucose production. Additionally, CTRP6 exhibits anti-inflammatory properties by inhibiting pro-inflammatory cytokine secretion in macrophages, potentially linking it to metabolic disorders like obesity and type 2 diabetes.

Recombinant C1qtnf6 protein, produced via bacterial or mammalian expression systems, enables researchers to study its biochemical and physiological mechanisms in vitro and in vivo. Its recombinant form retains native structure and activity, allowing exploration of therapeutic potential. For instance, exogenous CTRP6 administration in rodent models improves glucose tolerance and reduces adipose tissue inflammation, underscoring its relevance in metabolic disease research.

Despite progress, challenges remain in understanding CTRP6’s precise signaling pathways and receptor interactions. Structural complexity, including post-translational modifications, complicates large-scale production of bioactive recombinant protein. Current research focuses on elucidating its tissue-specific functions and cross-talk with other adipokines, which may unveil novel targets for metabolic syndrome therapeutics. Overall, CTRP6 represents a promising yet understudied player in metabolic and immune regulation.