| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2 |
| Entrez GeneID | 3588 |
| clone | 3A6C2 |
| WB Predicted band size | 37kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IL10RB(AA: 20-220) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于IL10RB抗体的模拟参考文献示例(请注意，内容为虚构，仅作格式参考)：
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1. **标题**: "IL10RB-Specific Antibodies Modulate Intestinal Inflammation in Murine Colitis Models"
**作者**: Kuhn, R. et al.
**摘要**: 研究开发了靶向IL10RB的单克隆抗体，发现其通过阻断IL-10信号通路加剧实验性结肠炎小鼠模型的炎症反应，提示IL10RB在肠道免疫稳态中的关键作用。
2. **标题**: "Structural Characterization of IL10RB and Antibody Binding Epitopes by Cryo-EM"
**作者**: Smith, J. & Wang, L.
**摘要**: 利用冷冻电镜解析IL10RB的分子结构，并筛选出高亲和力抗体，揭示其结合表位对IL-10/IL-22受体复合物功能的影响，为靶向治疗提供结构基础。
3. **标题**: "Anti-IL10RB Antibodies Enhance Antitumor Immunity in Solid Tumors"
**作者**: Zhang, Y. et al.
**摘要**: 在小鼠肿瘤模型中，阻断IL10RB的抗体通过抑制调节性T细胞功能，增强CD8+ T细胞介导的抗肿瘤活性，表明其作为癌症免疫治疗新策略的潜力。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“IL10RB antibody”或“anti-IL10RB”，并筛选近年相关研究。
The IL-10 receptor beta (IL10RB) antibody targets a critical component of the interleukin-10 (IL-10) signaling pathway. IL10RB, also known as IL-10R2 or CDw210b, is a transmembrane protein that forms part of the type II cytokine receptor family. It pairs with IL-10 receptor alpha (IL10RA) to create a functional heterodimeric receptor complex for IL-10. a potent anti-inflammatory cytokine. Unlike IL10RA, which is specific to IL-10. IL10RB also serves as a shared subunit for receptors of other cytokines, including IL-22. IL-26. and IL-28A/IL-29. broadening its role in immune regulation.
IL10RB antibodies are widely used in research to study receptor expression, signaling mechanisms, and dysregulation in diseases. Mutations in the IL10RB gene are linked to severe early-onset inflammatory bowel disease (IBD), highlighting its importance in immune homeostasis. Antibodies against IL10RB enable detection of receptor localization in immune cells (e.g., macrophages, T cells) and assessment of downstream STAT3 phosphorylation. Neutralizing antibodies are employed to block IL-10 signaling, aiding in functional studies of immune suppression or tumor microenvironments.
Commercial IL10RB antibodies include monoclonal and polyclonal variants validated for applications like flow cytometry, Western blotting, and immunohistochemistry. Their development supports translational research into autoimmune disorders, chronic inflammation, and cancer immunotherapy, where IL-10 pathways are therapeutic targets.
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