Recombinant Human GPR107 protein

中文名： 蛋白GPR107(GPR107)重组蛋白
别名： GPR107；KIAA1624；LUSTR1；Protein GPR107

货号: PA2000-5122

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>90%SDS-PAGE.
种属	Human
靶点	GPR107
Uniprot No	Q5VW38
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	40-263aa
氨基酸序列	RVHHLALKDDVRHKVHLNTFGFFKDGYMVVNVSSLSLNEPEDKDVTIGFSLDRTKNDGFSSYLDEDVNYCILKKQSVSVTLLILDISRSEVRVKSPPEAGTQLPKIIFSRDEKVLGQSQEPNVNPASAGNQTQKTQDGGKSKRSTVDSKAMGEKSFSVHNNGGAVSFQFFFNISTDDQEGLYSLYFHKCLGKELPSDKFTFSLDIEITEKNPDSYLSAGEIPLP
预测分子量	32.4 kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于GPR107重组蛋白的模拟参考文献示例(建议通过学术数据库核实具体文献信息)：

1. **文献名称**: "GPR107 mediates Golgi stress-induced apoptosis via the mTOR signaling pathway"

**作者**: Liu Y, et al.

**摘要**: 本研究阐明了GPR107重组蛋白在细胞应激反应中的作用，发现其通过调控mTOR通路介导高尔基体应激相关的细胞凋亡，为癌症治疗的靶点研究提供了新方向。

2. **文献名称**: "Structural characterization of recombinant GPR107 and its interaction with retrograde transport machinery"

**作者**: Smith J, et al.

**摘要**: 通过冷冻电镜解析了GPR107重组蛋白的三维结构，揭示了其与逆向运输复合体(retromer)的结合机制，为理解细胞内囊泡运输的分子基础提供了结构依据。

3. **文献名称**: "GPR107 knockdown suppresses tumor growth by inhibiting Wnt/β-catenin signaling in colorectal cancer"

**作者**: Chen X, et al.

**摘要**: 利用GPR107重组蛋白模型证明其在结直肠癌中通过激活Wnt/β-catenin通路促进肿瘤增殖，基因沉默可显著抑制体内外肿瘤生长。

4. **文献名称**: "GPR107 regulates hepatic insulin sensitivity through endosomal trafficking of insulin receptors"

**作者**: Wang H, et al.

**摘要**: 研究发现肝脏特异性GPR107重组蛋白过表达会干扰胰岛素受体的内体循环，导致胰岛素信号传导障碍，这为2型糖尿病发病机制提供了新解释。

**备注**：以上内容为模拟生成，实际文献需通过PubMed/Web of Science等平台以关键词"GPR107 recombinant"检索确认。建议结合研究具体方向(如疾病模型、信号通路)进一步筛选文献。

背景信息

**Background of GPR107 Recombinant Protein**

GPR107 (G Protein-Coupled Receptor 107) is a member of the large G protein-coupled receptor (GPCR) superfamily, which plays critical roles in cellular signal transduction. Classified as an orphan receptor, GPR107 lacks a definitively identified endogenous ligand, limiting its fully characterized physiological role. However, emerging studies suggest its involvement in diverse biological processes, including vesicular trafficking, cellular stress responses, and modulation of neurotransmitter systems. Structurally, it features seven transmembrane domains, a hallmark of GPCRs, and is evolutionarily conserved across eukaryotes, underscoring its functional significance.

GPR107 has garnered attention for its potential link to disease pathways. Research implicates it in cancer progression, where it may regulate tumor cell proliferation and metastasis. Additionally, its expression in neuronal tissues hints at roles in neurodegenerative disorders, such as Alzheimer’s disease, though mechanistic insights remain sparse. The receptor’s interaction with intracellular proteins, like the COPI vesicle transport machinery, further connects it to Golgi apparatus function and protein sorting, suggesting broader regulatory impacts.

Recombinant GPR107 protein, produced via heterologous expression systems (e.g., mammalian cells or *E. coli*), enables structural and functional studies. Its purified form facilitates ligand-binding assays, antibody development, and drug screening, aiding efforts to de-orphanize the receptor. By elucidating GPR107’s signaling pathways and interactome, researchers aim to uncover therapeutic targets for diseases linked to its dysregulation. Despite progress, challenges persist in mapping its precise physiological ligands and downstream effectors, highlighting the need for continued investigation into this enigmatic receptor.