| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL10RA; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1 |
| Entrez GeneID | 3587 |
| clone | 4D3A9 |
| WB Predicted band size | 63kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD210 (AA: extra 22-235) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD210(IL-10Rα)抗体的3篇代表性文献的简要信息：
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1. **文献名称**：*Interleukin-10 and the Interleukin-10 Receptor*
**作者**：Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A
**摘要**：该综述系统阐述了IL-10及其受体(包括CD210/IL-10Rα)的免疫调节功能，强调其在抑制炎症反应和维持免疫稳态中的作用，并讨论了靶向IL-10信号通路的潜在治疗策略。
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2. **文献名称**：*Targeting IL-10 receptor signaling in macrophages via antibody-mediated delivery of siRNA*
**作者**：He C, Hu X, Weston TA, Jung RS, Sandoval NP, Tontonoz P, et al.
**摘要**：研究利用CD210抗体作为靶向载体，将siRNA递送至表达IL-10Rα的巨噬细胞，验证了该策略在调控脂代谢相关基因ABCA1中的有效性，为精准免疫治疗提供了新方法。
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3. **文献名称**：*IL-10 receptor signaling is critical for the development of experimental autoimmune encephalomyelitis*
**作者**：Zhang X, Edwards JP, Mosser DM
**摘要**：通过CD210抗体阻断IL-10Rα信号，发现IL-10通路在多发性硬化症模型(EAE)中的保护性作用，提示IL-10Rα可能成为自身免疫疾病治疗的分子靶点。
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以上文献涵盖基础机制、技术应用及疾病模型研究，反映了CD210抗体在免疫调节与治疗中的多重价值。
CD210 antibody targets the interleukin-10 receptor alpha (IL-10Rα), a key component of the IL-10 receptor complex. IL-10 is an anti-inflammatory cytokine critical for modulating immune responses, and its receptor consists of two subunits: IL-10Rα (CD210) and IL-10Rβ. CD210 is primarily expressed on immune cells, including T cells, B cells, macrophages, and dendritic cells, facilitating IL-10-mediated signaling to suppress excessive inflammation and maintain immune homeostasis. The binding of IL-10 to CD210 activates the JAK1/TYK2-STAT3 pathway, regulating genes involved in anti-inflammatory responses and cell survival.
CD210 antibodies are widely used in research to study IL-10 signaling mechanisms, immune regulation, and diseases linked to IL-10 pathway dysregulation, such as autoimmune disorders, chronic infections, and cancers. These antibodies enable detection of CD210 expression via techniques like flow cytometry, immunohistochemistry, and Western blot. Additionally, therapeutic applications are explored, as blocking CD210 may counteract immunosuppressive environments in tumors or enhance inflammatory responses in persistent infections. However, aberrant IL-10 signaling is also implicated in inflammatory bowel disease and lupus, making CD210 a potential biomarker or therapeutic target. CD210 antibodies thus serve as essential tools for both basic research and translational studies in immunology and oncology.
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