Mouse Monoclonal CD42A Antibody

The CD42a antibody targets the CD42a antigen, also known as glycoprotein IX (GPIX), a key component of the platelet membrane glycoprotein Ib-IX-V (GPIb-IX-V) complex. This complex plays a critical role in primary hemostasis by mediating platelet adhesion to von Willebrand factor (VWF) at sites of vascular injury. GPIX, encoded by the GP9 gene, forms a stable non-covalent complex with GPIbα (CD42b) and GPIbβ (CD42c), which is essential for maintaining receptor stability and surface expression. CD42a antibodies are widely utilized in research and diagnostics to study platelet function, monitor platelet disorders, or identify inherited bleeding conditions like Bernard-Soulier syndrome (BSS), where mutations in GP9 lead to defective platelet aggregation. In clinical settings, CD42a antibodies are employed in flow cytometry to quantify platelet populations or assess activation status. Additionally, autoimmune antibodies against CD42a have been implicated in rare thrombocytopenic disorders. The development of CD42a-targeting tools has advanced understanding of thrombus formation, platelet-endothelium interactions, and pathological mechanisms in cardiovascular diseases. Recent studies also explore its potential as a therapeutic target for antiplatelet therapies or platelet-specific drug delivery systems.