| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CSS9; MRD27 |
| Entrez GeneID | 6664 |
| clone | 1A6C10 |
| WB Predicted band size | 46.7kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SOX11 (AA: 1-250) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SOX11抗体的3篇代表性文献，按研究领域和内容整理：
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1. **文献名称**：SOX11 expression in mantle cell lymphoma: Diagnostic and prognostic implications
**作者**：Ek S, Dictor M, Jerkeman M, et al.
**摘要**：该研究通过免疫组化分析SOX11在套细胞淋巴瘤(MCL)中的表达，证明其作为MCL诊断标志物的高特异性，并提示高SOX11水平与不良预后相关，支持其在临床病理学中的应用。
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2. **文献名称**：SOX11 is a sensitive and specific antibody for detection of mantle cell lymphoma
**作者**：Barrans S, Crouch S, Care MA, et al.
**摘要**：研究比较了不同SOX11抗体的敏感性和特异性，发现特定克隆号抗体(如克隆MRQ-58)在MCL诊断中表现优异，强调了抗体选择对准确诊断的重要性。
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3. **文献名称**：SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in neuroblastoma
**作者**：Shern JF, Chen L, Chmielecki J, et al.
**摘要**：该研究利用SOX11抗体探究其在神经母细胞瘤中的功能，发现SOX11通过调控PDGFA促进血管生成，为靶向治疗提供了潜在方向。
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4. **文献名称**：SOX11 expression in ovarian carcinoma
**作者**：Köbel M, Bak J, Bertelsen BI, et al.
**摘要**：通过免疫组化分析卵巢癌组织，研究发现SOX11表达与肿瘤分化程度相关，高表达可能预示更差的生存结局，提示其作为预后标志物的潜力。
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以上文献涵盖了SOX11抗体在淋巴瘤、神经肿瘤及实体瘤中的诊断、预后及机制研究，反映了其多领域应用价值。具体引用时建议通过PubMed或Web of Science核对原文信息。
The SOX11 antibody is a valuable tool in biomedical research and diagnostics, targeting the SOX11 protein encoded by the *SOX11* gene, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX11 plays critical roles in embryonic development, neurogenesis, and tissue regeneration, with emerging implications in cancer biology. It regulates gene expression by binding to DNA through its HMG domain, influencing cell differentiation, proliferation, and survival.
In oncology, SOX11 has gained attention as a biomarker for mantle cell lymphoma (MCL), where its overexpression aids in distinguishing MCL from other B-cell malignancies. Antibodies against SOX11 are widely used in immunohistochemistry (IHC) to detect nuclear SOX11 expression in tumor samples, enhancing diagnostic accuracy. Additionally, SOX11 is implicated in other cancers, including epithelial ovarian cancer and gliomas, where its expression correlates with tumor progression or prognosis.
SOX11 antibodies are typically developed using immunogenic peptides or recombinant proteins, validated for specificity in assays like Western blotting, IHC, and immunofluorescence. Challenges include cross-reactivity with homologous SOX proteins (e.g., SOX4. SOX12) due to conserved HMG domains, necessitating careful validation. Research applications extend to studying SOX11’s role in neural development, wound healing, and regenerative medicine.
Overall, SOX11 antibodies are pivotal in elucidating the protein’s dual roles in development and disease, offering insights into molecular pathways and potential therapeutic targets.
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