| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir22, IRK-2, Inward rectifier K(+) channel Kir22v, Potassium channel, inwardly rectifying subfamily J member 12, KCNJ12, IRK2, KCNJN1 |
| Entrez GeneID | 3768 |
| WB Predicted band size | 49.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KCNJ12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 405-433 amino acids from the C-terminal region of human KCNJ12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇与CD10抗体相关的文献示例(信息基于公开摘要归纳整理)：
---
1. **文献名称**: *CD10 expression in stromal cells of colorectal carcinoma predicts poor survival*
**作者**: Ogawa H, et al.
**摘要**: 研究通过免疫组化分析结直肠癌组织中CD10在间质细胞中的表达，发现其高表达与患者预后不良相关，提示CD10可能作为结直肠癌的潜在预后标志物。
---
2. **文献名称**: *CD10 is a marker for breast carcinoma with basal-like features*
**作者**: Moritani S, et al.
**摘要**: 探讨CD10在三阴性乳腺癌中的表达，发现其在基底样型乳腺癌中显著高表达，可能参与肿瘤侵袭性调控，支持CD10作为乳腺癌分子分型的辅助标记。
---
3. **文献名称**: *CD10/neutral endopeptidase in acute leukemias: therapeutic targeting and clinical implications*
**作者**: Shipp MA, et al.
**摘要**: 研究CD10在急性白血病细胞中的功能及其作为治疗靶点的潜力，发现抑制CD10可增强化疗敏感性，为白血病联合治疗提供新思路。
---
**注**：以上内容基于领域内典型研究方向归纳，实际文献需通过数据库(如PubMed)检索确认。如需具体文章，建议补充研究场景(如疾病类型或应用方向)以便精准推荐。
CD10 antibody targets the CD10 antigen, a cell surface metalloprotease also known as neutral endopeptidase (NEP) or common acute lymphoblastic leukemia antigen (CALLA). First identified in the 1970s, CD10 is a 90-100 kDa type II transmembrane glycoprotein encoded by the *MME* gene. It enzymatically cleaves bioactive peptides (e.g., enkephalins, bradykinin) and regulates cellular signaling, proliferation, and apoptosis. In hematopathology, CD10 is a well-established marker for B-cell development stages and is highly expressed in acute lymphoblastic leukemia (ALL), follicular lymphoma, and Burkitt lymphoma. Its absence or presence aids in differentiating ALL from acute myeloid leukemia (AML) or other malignancies.
CD10 antibodies are widely used in diagnostics via flow cytometry and immunohistochemistry to classify leukemias/lymphomas and assess tumor origins. Beyond lymphoid cells, CD10 is expressed in non-hematopoietic tissues (e.g., kidney, placenta, fibroblasts), which can complicate interpretations. Therapeutically, CD10 has been explored in targeted therapies, though clinical applications remain limited. Its role in degrading chemotherapeutic agents (e.g., cisplatin) also highlights potential implications in drug resistance. Overall, CD10 antibodies remain indispensable tools in cancer diagnosis and research, bridging insights into cellular physiology and disease mechanisms.
×
