| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/50 - 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | NAP; P14L; PP8304; C20orf33; dJ633O20.1 |
| Entrez GeneID | 56259 |
| clone | 3C7F9 |
| WB Predicted band size | 65kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CTNNBL1 (AA: 390-557) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CTNNBL1抗体的模拟参考文献(非真实存在，仅供示例)：
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1. **"Characterization of a Novel Monoclonal Antibody Against CTNNBL1 for Immunoblotting Applications"**
*Author: Smith J, et al.*
摘要：本研究报道了一种针对人CTNNBL1蛋白的新型单克隆抗体的开发与验证。通过Western blot和免疫荧光实验证明该抗体特异性识别CTNNBL1.并应用于探究CTNNBL1在不同癌细胞系中的表达差异。
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2. **"CTNNBL1 Antibody Reveals Its Role in Pre-mRNA Splicing Regulation"**
*Author: Lee H, et al.*
摘要：利用特异性CTNNBL1抗体进行免疫共沉淀(Co-IP)实验，发现CTNNBL1与剪接体复合物相互作用，提示其在pre-mRNA剪接中的功能，为研究基因表达调控机制提供新线索。
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3. **"Development of a Polyclonal Antibody for CTNNBL1 and Its Application in Adipose Tissue Studies"**
*Author: Garcia R, et al.*
摘要：报道了一种兔源多克隆抗体的制备，并通过免疫组化证实CTNNBL1在肥胖模型小鼠脂肪组织中的表达上调，提示其与脂代谢疾病的潜在关联。
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注：以上文献为示例性内容，实际研究中请通过PubMed或Web of Science等平台检索真实文献。
**Background of CTNNBL1 Antibody**
CTNNBL1 (Catenin Beta Like 1) is a protein encoded by the *CTNNBL1* gene, belonging to the β-catenin family. Though structurally similar to β-catenin, it lacks direct involvement in canonical Wnt signaling. Instead, CTNNBL1 is implicated in diverse cellular processes, including mRNA splicing, protein-protein interactions, and regulation of metabolic pathways. Studies suggest its role in modulating the activity of activation-induced cytidine deaminase (AID), essential for antibody diversification, and its interaction with components of the spliceosome complex.
CTNNBL1 antibodies are critical tools for investigating its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study CTNNBL1's involvement in diseases such as obesity, cancer, and immunological disorders. For instance, altered CTNNBL1 expression has been linked to adipogenesis regulation and tumor progression, highlighting its potential as a therapeutic or diagnostic target.
The protein’s HEAT-repeat domains mediate interactions with partners like PPP1R3 proteins, influencing glycogen metabolism. Antibodies targeting specific epitopes help dissect these molecular mechanisms. Research also explores CTNNBL1's genetic variants associated with human traits, including body mass index (BMI), underscoring its relevance in personalized medicine. Overall, CTNNBL1 antibodies serve as vital reagents for unraveling the protein's multifaceted roles in health and disease.
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