Mouse Monoclonal P2RY1 Antibody

The P2RY1 antibody targets the P2Y purinoceptor 1 (P2RY1), a G protein-coupled receptor (GPCR) activated by extracellular nucleotides like ATP and ADP. Identified in the early 1990s, P2RY1 plays critical roles in cellular signaling, particularly in platelets, the nervous system, and immune cells. It couples with Gq proteins to mobilize intracellular calcium, influencing processes such as platelet aggregation, neurotransmission, and inflammatory responses. Dysregulation of P2RY1 is linked to thrombosis, neurodegenerative disorders, and immune dysfunctions. Antibodies against P2RY1 are essential tools for studying its expression, localization, and function. They enable detection in tissues or cells via techniques like Western blot, immunohistochemistry, and flow cytometry. Recent research explores P2RY1's therapeutic potential, with antibodies aiding in validating its role in disease models or screening targeted drugs. Challenges include ensuring antibody specificity due to structural similarities among purinergic receptors. Advances in monoclonal antibody technology have improved selectivity, supporting mechanistic studies and translational applications. Overall, P2RY1 antibodies remain pivotal in unraveling the receptor's physiological and pathological significance.