Mouse Monoclonal P2RY8 Antibody

The P2RY8 antibody is designed to target the P2Y purinoceptor 8 (P2RY8), a G protein-coupled receptor (GPCR) belonging to the P2Y receptor family. P2RY8 is activated by extracellular diadenosine polyphosphates (e.g., Ap4A) and nucleotides like ADP, playing roles in immune regulation, cell proliferation, and inflammation. It couples to Gαi/o proteins, inhibiting cAMP signaling, and is implicated in diseases such as cancer and autoimmune disorders. In research, P2RY8 antibodies are critical tools for detecting receptor expression via techniques like Western blotting, immunofluorescence, or flow cytometry. These antibodies help elucidate P2RY8's tissue distribution, signaling mechanisms, and pathological relevance. Notably, P2RY8 has gained attention in lymphoma studies, where chromosomal rearrangements (e.g., with MYC) and dysregulated expression are linked to oncogenesis. Commercially available P2RY8 antibodies are often validated for specificity using knockout cell lines or blocking peptides. Challenges include cross-reactivity with other P2Y receptors due to structural homology. Researchers prioritize antibodies with proven applications in their experimental models (human, mouse, etc.). Understanding P2RY8's role in immune-cell migration and tumor microenvironments may advance therapeutic strategies targeting purinergic signaling pathways.