| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | C3-C5; METH1 |
| Entrez GeneID | 9510 |
| clone | 1G5D5 |
| WB Predicted band size | 105.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ADAMTS1 (AA: 858-960) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4条关于ADAMTS1抗体的模拟参考文献示例(基于类似研究方向的文献框架整理)：
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1. **文献名称**：*ADAMTS1: A Key Regulator of Tumor Angiogenesis and Metastasis*
**作者**：Smith JR, et al.
**摘要**：研究利用特异性ADAMTS1抗体，通过免疫组化分析发现其在多种肿瘤组织中高表达，并通过抑制VEGF信号通路调控肿瘤血管生成，提示其作为癌症治疗潜在靶点。
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2. **文献名称**：*ADAMTS1 Modulates Extracellular Matrix Remodeling in Myocardial Infarction*
**作者**：Li X, et al.
**摘要**：通过Western blot和免疫荧光技术(使用ADAMTS1抗体)，揭示ADAMTS1在心肌梗死后心脏组织中的动态表达变化，其通过降解versican蛋白参与心肌纤维化过程。
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3. **文献名称**：*ADAMTS1 Antibody-Based Detection of Inflammatory Biomarkers in Rheumatoid Arthritis*
**作者**：Garcia M, et al.
**摘要**：开发高灵敏度ADAMTS1单克隆抗体，用于ELISA检测类风湿关节炎患者滑液中的ADAMTS1水平，发现其与炎症程度正相关，提示临床诊断价值。
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4. **文献名称**：*ADAMTS1 Knockdown Suppresses Ovarian Cancer Cell Invasion via Antibody-Mediated Functional Blockade*
**作者**：Wang Y, et al.
**摘要**：研究使用中和性ADAMTS1抗体阻断其蛋白水解活性，证实ADAMTS1通过调控细胞外基质降解促进卵巢癌细胞侵袭，为靶向治疗提供依据。
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(注：以上文献为示例，实际引用需以真实发表的论文为准。)
**Background of ADAMTS1 Antibody**
ADAMTS1 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 1) is a secreted extracellular matrix (ECM)-associated protease belonging to the ADAMTS family. It plays critical roles in tissue remodeling, angiogenesis inhibition, inflammation, and organ development by cleaving components like aggrecan, versican, and thrombospondin. Structurally, ADAMTS1 contains a prodomain, metalloproteinase domain, disintegrin-like module, thrombospondin type-1 repeats (TSR), and a spacer region, which collectively mediate substrate specificity and interactions with ECM proteins.
ADAMTS1 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts, such as cancer, cardiovascular diseases, and osteoarthritis. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to detect ADAMTS1 in various biological samples. Researchers often prioritize antibodies validated for specificity through knockout controls or immunoprecipitation, as ADAMTS1 shares structural homology with other ADAMTS members.
Due to its involvement in disease pathways, ADAMTS1 antibodies also aid in exploring therapeutic targets. However, factors like species reactivity (e.g., human, mouse, rat), post-translational modifications (e.g., glycosylation), and epitope accessibility must be considered during antibody selection. Commercial antibodies may vary in clonality (monoclonal vs. polyclonal) and application suitability, necessitating careful validation for experimental reproducibility.
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