| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | LKLF |
| Entrez GeneID | 10365 |
| clone | 2F12A11 |
| WB Predicted band size | 37.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human KLF2 (AA: 251-355) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于KLF2抗体的参考文献示例(内容为学术场景模拟，非真实文献)：
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1. **文献名称**：*KLF2 regulates T-cell activation and differentiation through NF-κB signaling*
**作者**：Smith J. et al.
**摘要**：本研究利用KLF2特异性抗体，通过Western blot和染色质免疫沉淀(ChIP)技术，揭示KLF2通过抑制NF-κB通路调控T细胞活化和分化，为自身免疫疾病治疗提供新靶点。
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2. **文献名称**：*Endothelial KLF2 mediates anti-inflammatory effects in atherosclerosis*
**作者**：Lee H. et al.
**摘要**：通过免疫组化及KLF2抗体检测，发现KLF2在内皮细胞中高表达可抑制促炎因子(如VCAM-1)，延缓动脉粥样硬化进展，证明KLF2是血管稳态的关键调节因子。
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3. **文献名称**：*KLF2 suppression promotes tumor metastasis via EMT pathway*
**作者**：Wang Q. et al.
**摘要**：使用KLF2抗体分析癌症组织样本，发现KLF2低表达与上皮-间质转化(EMT)显著相关，提示其通过抑制MMP9等蛋白抑制肿瘤转移，可能成为预后标志物。
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注：以上文献为示例性内容，实际研究中建议通过PubMed或Web of Science检索真实文献。如需具体文章推荐，可提供研究方向或实验场景进一步协助。
**Background of KLF2 Antibody**
The KLF2 (Krüppel-like factor 2) antibody is a crucial tool for studying the expression and function of KLF2. a transcription factor belonging to the Krüppel-like factor (KLF) family. KLF2 regulates diverse biological processes, including immune regulation, vascular endothelial cell homeostasis, glucose metabolism, and adipogenesis. It is notably involved in T-cell survival, differentiation, and suppression of pro-inflammatory responses, making it a key player in immune tolerance and cardiovascular health.
KLF2 antibodies are widely used in research to detect KLF2 protein levels via techniques like Western blotting, immunohistochemistry, and flow cytometry. These antibodies aid in exploring KLF2's role in diseases such as atherosclerosis, cancer, and autoimmune disorders. For instance, reduced KLF2 expression is linked to endothelial dysfunction in cardiovascular diseases, while its upregulation in certain cancers may influence tumor progression.
Developed in various host species (e.g., rabbit, mouse), KLF2 antibodies are validated for specificity and sensitivity, often through knockout (KO) controls or siRNA knockdown experiments. Their applications extend to preclinical studies, helping to elucidate KLF2's interactions with signaling pathways like NF-κB and MAPK. As KLF2 gains attention as a therapeutic target, its antibody remains indispensable for mechanistic and translational research in immunology, oncology, and vascular biology.
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