Mouse Monoclonal ATG16L1 Antibody

The ATG16L1 antibody is a crucial tool in autophagy research, targeting the autophagy-related 16-like 1 (ATG16L1) protein, a key component of the cellular autophagy machinery. Autophagy is a conserved process for degrading cytoplasmic components, and ATG16L1 plays a central role in autophagosome formation by forming a complex with ATG12-ATG5. which facilitates LC3 lipidation and membrane elongation. Dysregulation of ATG16L1 is linked to various diseases, notably inflammatory bowel disease (IBD), particularly Crohn's disease, where the T300A polymorphism in ATG16L1 increases susceptibility. This mutation disrupts autophagy-mediated clearance of intracellular pathogens and regulation of the gut microbiota, contributing to chronic inflammation. Researchers use ATG16L1 antibodies to study its expression, localization, and interactions in tissues or cell models, aiding in understanding autophagy mechanisms and disease pathogenesis. These antibodies are widely applied in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Their development has advanced insights into how ATG16L1 variants influence immune responses, microbial handling, and cellular homeostasis, highlighting their relevance in both basic research and potential therapeutic targeting for autophagy-related disorders.