Mouse Monoclonal RAB11FIP1 Antibody

The RAB11FIP1 antibody targets the Rab11 family-interacting protein 1 (RAB11FIP1), a key player in intracellular vesicular trafficking and membrane dynamics. RAB11FIP1 belongs to the Rab11 effector protein family, which regulates Rab11 GTPase-dependent processes such as endocytic recycling, cytokinesis, and polarized exocytosis. Structurally, RAB11FIP1 contains an N-terminal Rab11-binding domain and a C-terminal membrane-binding region, enabling its role in tethering vesicles to specific cellular compartments. It is implicated in diverse cellular functions, including neurite outgrowth, autophagy, and receptor transport, and has been linked to pathologies such as cancer and neurological disorders. Antibodies against RAB11FIP1 are widely used in research to study its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These tools help elucidate its mechanistic roles in membrane trafficking pathways and disease contexts. Commercial RAB11FIP1 antibodies are typically developed in hosts like rabbits or mice, with validation across human, mouse, and rat samples. Studies using these antibodies have highlighted RAB11FIP1's involvement in tumor progression, synaptic plasticity, and ciliogenesis, underscoring its significance as a biomarker and therapeutic target in cellular and disease biology research.