| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | LH2; hLhx2; MGC138390; LHX2 |
| Entrez GeneID | 9355 |
| clone | 6G2 |
| WB Predicted band size | 44kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LHX2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LHX2抗体的示例参考文献(内容为模拟，仅供参考，实际文献请通过学术数据库查询)：
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1. **文献名称**：*Lhx2 regulates cortical interneuron development*
**作者**：Porter FD, et al.
**摘要**：研究利用LHX2抗体进行免疫染色，发现LHX2在小鼠端脑发育中调控中间神经元的迁移和分化，缺失LHX2会导致皮层抑制性神经元异常。
2. **文献名称**：*LHX2 controls the timing of cortical astrogenesis*
**作者**：Yun K, et al.
**摘要**：通过LHX2抗体的Western blot和免疫组化分析，证明LHX2通过调控Notch信号通路影响皮质星形胶质细胞的生成时间，影响大脑皮层结构。
3. **文献名称**：*LHX2 maintains hematopoietic stem cell self-renewal*
**作者**：Hiratani I, Mika S.
**摘要**：研究使用LHX2抗体检测胚胎造血干细胞，发现LHX2通过结合靶基因启动子区维持干细胞的自我更新能力，缺失后导致造血功能异常。
4. **文献名称**：*LHX2 in hair follicle regeneration*
**作者**：Li J, et al.
**摘要**：通过皮肤组织切片中LHX2抗体的定位分析，揭示LHX2通过调控Wnt/β-catenin通路促进毛囊干细胞激活，影响毛发周期再生过程。
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**注意**：以上为模拟生成的参考文献，实际研究中请通过PubMed、Google Scholar等平台以“LHX2 antibody”为关键词检索并核对原文。
The LHX2 antibody is a crucial tool in developmental biology and neuroscience research, targeting the LIM Homeobox 2 (LHX2) protein, a member of the LIM-homeodomain transcription factor family. LHX2 plays pivotal roles in embryonic development, particularly in nervous system patterning, retinal development, and organogenesis. It regulates gene expression by binding DNA through its homeodomain and interacting with other proteins via its LIM domains. Studies highlight its involvement in maintaining neural stem cell populations, guiding axonal projections, and ensuring proper differentiation of sensory organs.
Researchers use LHX2 antibodies primarily in techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to visualize protein expression and localization in tissues or cultured cells. These applications have revealed LHX2's dynamic expression in the developing brain, eye, and hematopoietic systems. Aberrant LHX2 expression is linked to pathologies, including glioblastoma and breast cancer, making its antibody a valuable probe for oncological studies. Commercial LHX2 antibodies are typically raised in rabbits or mice, validated for specificity using knockout controls or siRNA-mediated knockdown. Their utility spans basic developmental studies, disease mechanism exploration, and potential therapeutic target identification.
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