| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, 3126-, Ern1 {ECO:0000312|MGI:MGI:1930134} |
| Entrez GeneID | 78943 |
| WB Predicted band size | 110.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Ern1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 827-855 amino acids from the C-terminal region of mouse Ern1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与KDM3A抗体相关的文献示例(注：文献信息为模拟概括，实际引用需核实原始论文)：
1. **文献名称**：*KDM3A regulates transcriptional activation of genes promoting hepatocellular carcinoma progression through H3K9 demethylation*
**作者**：Li Y, et al.
**摘要**：研究利用KDM3A特异性抗体进行ChIP-seq和免疫组化，揭示KDM3A通过去除H3K9me2修饰激活促癌基因(如MYC)，驱动肝癌细胞增殖和转移。
2. **文献名称**：*KDM3A interacts with hypoxia-inducible factor 1α to enhance metabolic reprogramming in solid tumors*
**作者**：Wang X, et al.
**摘要**：通过Western blot和免疫共沉淀(使用KDM3A抗体)，证实KDM3A在缺氧条件下与HIF-1α协同调控糖酵解相关基因，促进肿瘤代谢适应。
3. **文献名称**：*Androgen receptor signaling requires KDM3A-mediated histone demethylation for prostate cancer cell invasion*
**作者**：Sharma S, et al.
**摘要**：利用KDM3A抗体进行染色质分析，发现KDM3A通过去甲基化雄激素受体靶基因区域的H3K9me2.增强前列腺癌细胞侵袭能力。
如需具体文献，建议在PubMed或Web of Science中检索“KDM3A antibody”及相关关键词，筛选应用该抗体的功能研究论文。
The KDM3A antibody is a tool used to detect and study KDM3A (Lysine Demethylase 3A), a member of the Jumonji domain-containing histone demethylase family. KDM3A, also known as JMJD1A, specifically demethylates histone H3 lysine 9 mono- and di-methylation (H3K9me1/me2), epigenetic marks associated with transcriptional repression. This enzyme plays critical roles in regulating gene expression, cellular differentiation, and metabolic processes. It is implicated in diverse biological functions, including spermatogenesis, energy homeostasis, hypoxia response, and cancer progression. In cancer, KDM3A overexpression is linked to tumor growth, metastasis, and therapy resistance by modulating oncogenic pathways and suppressing apoptosis.
The KDM3A antibody is widely utilized in research to analyze protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry. Its application helps uncover KDM3A's mechanistic roles in disease models, particularly in studying epigenetic dysregulation in malignancies. Recent studies also explore KDM3A's potential as a therapeutic target, driving interest in developing inhibitors. Researchers rely on validated KDM3A antibodies to ensure specificity and reproducibility in experiments, contributing to advancements in understanding epigenetic regulation and its implications in health and disease.
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