Mouse Monoclonal CDH2 Antibody

The CDH2 antibody targets cadherin-2 (CDH2), a calcium-dependent cell adhesion glycoprotein also known as N-cadherin. CDH2 plays a critical role in mediating cell-cell adhesion, tissue morphogenesis, and cell signaling during embryonic development and adult homeostasis. It is predominantly expressed in neural tissues, mesenchymal cells, and endothelial cells, and is implicated in processes such as neuronal circuit formation, wound healing, and cancer metastasis. In oncology, CDH2 overexpression is linked to epithelial-mesenchymal transition (EMT), a mechanism driving tumor invasiveness and resistance to therapy. CDH2 antibodies are widely used in research to study these biological processes, employing techniques like immunohistochemistry (IHC), Western blotting, and flow cytometry. They help detect CDH2 expression patterns in normal vs. diseased tissues, assess protein localization, and evaluate its role in cell adhesion dynamics. Commercially available CDH2 antibodies are typically raised in hosts like rabbits or mice, with validation across multiple applications. Recent studies also explore CDH2's involvement in neurodegenerative diseases and cardiovascular development, broadening its therapeutic relevance. Proper antibody validation remains essential due to potential cross-reactivity with other cadherin family members.