关键信息
-
基因名
NKp30/NCR3
- 应用
-
别名
CD337; 1C7; LY117; NKp30; Lymphocyte Antigen 117; Activating natural killer receptor p30; Natural killer cell p30-related protein
-
种属
Rat
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8CFD9
-
表达区间
Val23~Ser150
-
分子量
17kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NKp30, also known as NCR3 (Natural Cytotoxicity Receptor 3), is a pivotal activating receptor expressed on natural killer (NK) cells, playing a critical role in the immune response against tumors and viral infections. Research into NKp30/NCR3 has gained momentum due to its potential implications in cancer immunotherapy. Functionally, NKp30 interacts with various ligands found on tumor cells, leading to the activation of NK cells, which are essential for the recognition and lysis of malignant cells. The receptor's engagement is associated with the release of cytotoxic cytokines, enhancing the immune response. However, cancer cells often exploit mechanisms to downregulate or evade NK cell recognition, including the loss of NKp30 expression or the secretion of immunosuppressive factors. Understanding the structure and function of NKp30/NCR3, as well as its signaling pathways, is crucial for developing innovative therapeutic strategies that can reinvigorate NK cell activity against cancer. Additionally, recombinant NKp30 proteins are being investigated for their potential use in diagnostic and therapeutic applications, providing insights into the receptor's role in immune modulation. Thus, the study of NKp30/NCR3 is essential for harnessing the full potential of NK cells in immunotherapy, offering promising avenues for enhancing anti-tumor immunity and improving clinical outcomes in cancer patients.
