关键信息
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基因名
BAFFR/TNFRSF13C
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简介
BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation[1]. BAFFR/TNFRSF13C Protein, Cynomolgus (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 70 amino acids (S7-G76) and is produced in HEK293 cells.
- 应用
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别名
CD268; BAFFR; BR3; TNFRSF13C; BROMIX; CVID4; prolixin
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种属
Cynomolgus
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A0A2K5V1K1
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表达区间
S7-G76
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蛋白长度
Partial
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分子量
13-25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
BAFFR, also known as TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily Member 13C), is a crucial receptor involved in the regulation of B cell homeostasis and survival. It specifically binds to the B cell activating factor (BAFF), which is vital for B cell maturation and function. Dysregulation of the BAFF/BAFFR signaling pathway has been implicated in various autoimmune diseases and lymphoproliferative disorders, highlighting the receptor's potential as a therapeutic target. Research into BAFFR has revealed its role in modulating immune responses, influencing both antibody production and B cell apoptosis. Understanding the structural and functional characteristics of BAFFR is essential for developing specific inhibitors that could modulate its activity in disease contexts. Recombinant BAFFR proteins are used in various studies to elucidate its interactions with BAFF and other ligands, providing insights into its signaling mechanisms. Overall, the investigation of BAFFR offers promising avenues for innovative treatments in autoimmune and hematological diseases.
