关键信息
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基因名
IL-1R1
- 应用
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别名
CD121a; CD121-A; IL1-R1; IL1R; IL1RA; P80; CD121 Antigen-Like Family Member A; Interleukin-1 Receptor Alpha
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
> 95% as determined by SDS-PAGE.
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蛋白编号
P14778
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表达区间
Asp21~Ile109
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蛋白长度
Partial
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分子量
14kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Interleukin-1 receptor type 1 (IL-1R1) is a crucial component of the immune response, serving as the primary signaling receptor for interleukin-1 (IL-1), a pro-inflammatory cytokine involved in various physiological and pathological processes. The study of IL-1R1 has gained significant attention due to its role in mediating immune responses, particularly in inflammatory diseases, autoimmune disorders, and certain cancers. Dysregulation of IL-1R1 signaling has been linked to a range of health issues, making it a promising target for therapeutic interventions. Research in this area has focused on understanding the structural and functional dynamics of IL-1R1, the mechanisms by which it influences downstream signaling pathways, and its interactions with other proteins. Recombinant IL-1R1 protein plays a vital role in these studies, allowing for detailed investigations of the receptor's function, ligand binding characteristics, and potential modulation by small molecules or antibodies. Moreover, IL-1R1 recombinant proteins are also being developed for use in diagnostic kits and therapeutic strategies aimed at controlling inappropriate inflammatory responses. Overall, the ongoing research surrounding IL-1R1 recombinant protein is essential for advancing our understanding of immune regulation and developing effective treatments for a variety of inflammatory and autoimmune conditions.
