关键信息
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基因名
UBOX5
- 应用
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别名
UBOX5; KIAA0860; RNF37; UBCE7IP5; UIP5; RING finger Protein 37; EC 2.3.2.27; RING-type E3 ubiquitin transferase RNF37; U-box domain-containing Protein 5; UbcM4-interacting Protein 5; hUIP5; Ubiquitin-conjugating enzyme 7-interacting Protein 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94941
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表达区间
1-541 aa
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氨基酸序列
MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP VYVTVSFPFN VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR TLGPAEPSVP DKEAFTLVGK VLLKNQSQVV FSHRGFKARP PFGAMEATLP SPAVVAQELW NKGALSLSHV AHLRICITHV TGGGIPCIKR LEVWGQPAKT CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP ESQQAPSSLQ KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL AVIPSSIVLP SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA KKMKATNEPS LTHMDCSTGP LSHEQKLSQS LEIALASTLG SMPSFTARLT RGQLQHLGTR GSNTSWRPGT GSEQPGSILG PECASCKRVF SPYFKKEPVY QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH F
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分子量
58.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
UBOX5 is a member of the U-box protein family, which is characterized by a unique U-box structural motif that is involved in protein-protein interactions and ubiquitination processes. Research into UBOX5 has gained significance due to its potential role in cellular signaling pathways and its implications in various physiological and pathological conditions, including cancer and neurodegenerative diseases. Recent studies suggest that UBOX5 may influence the degradation of specific substrates by promoting their ubiquitination, thereby regulating protein turnover and modulating cellular responses to stress. Understanding the functional mechanisms of UBOX5 and its interactions with other cellular components could provide valuable insights into its contributions to disease mechanisms and open up new avenues for therapeutic interventions. Given the increasing interest in the U-box family of proteins in the context of targeted therapies and cellular regulation, UBOX5 is poised to become an important focus of research in molecular biology and biochemistry. Its study could lead to breakthroughs in understanding how protein homeostasis is maintained in cells and how dysregulation of these processes can lead to disease.
