关键信息
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基因名
TTRAP
- 应用
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别名
5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; AD 022; AD022; dJ30M3.3; EAP 2; EAP II; EAP2; EAPII; ETS 1 associated Protein 2; ETS 1 associated Protein II; ETS1 associated Protein 2; ETS1 associated Protein II; ETS1-associated Protein 2; ETS1-associated Protein II; MGC111021; MGC9099; RP1-30M3.3; tdp2; TRAF and TNF receptor associated Protein; TRAF and TNF receptor-associated Protein; TTRAP; TYDP2_HUMAN; Tyr DNA phosphodiesterase 2; Tyr-DNA phosphodiesterase 2; Tyrosyl DNA phosphodiesterase 2; Tyrosyl-DNA phosphodiesterase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95551
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表达区间
1-362 aa
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氨基酸序列
MELGSCLEGG REAAEEEGEP EVKKRRLLCV EFASVASCDA AVAQCFLAEN DWEMERALNS YFEPPVEESA LERRPETISE PKTYVDLTNE ETTDSTTSKI SPSEDTQQEN GSMFSLITWN IDGLDLNNLS ERARGVCSYL ALYSPDVIFL QEVIPPYYSY LKKRSSNYEI ITGHEEGYFT AIMLKKSRVK LKSQEIIPFP STKMMRNLLC VHVNVSGNEL CLMTSHLEST RGHAAERMNQ LKMVLKKMQE APESATVIFA GDTNLRDREV TRCGGLPNNI VDVWEFLGKP KHCQYTWDTQ MNSNLGITAA CKLRFDRIFF RAAAEEGHII PRSLDLLGLE KLDCGRFPSD HWGLLCNLDI IL
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分子量
40.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TTRAP (TRAF and TNF receptor-associated protein) is a crucial protein involved in various cellular processes, including signal transduction, immune responses, and apoptosis. Research on TTRAP has intensified due to its role in modulating the activity of tumor necrosis factor (TNF) receptors and its implications in inflammatory diseases and cancer. As an adaptor protein, TTRAP interacts with a range of signaling molecules, influencing pathways such as NF-kB and MAPK, which are pivotal in cell survival and inflammatory responses. The potential involvement of TTRAP in regulating apoptosis offers insights into its function in tumorigenesis, making it a target of interest for therapeutic interventions. Recent studies have focused on the recombinant expression of TTRAP to elucidate its structural properties and functional mechanisms. These recombinant proteins are essential for performing biochemical assays and understanding TTRAP's interactions with other proteins, thus paving the way for novel drug development and targeting strategies in diseases linked to dysregulated TNF signaling. By generating TTRAP as a recombinant protein, researchers aim to gain deeper insights into its role in cellular dynamics and therapeutic potential, enhancing our understanding of diseases where TTRAP plays a critical role.
