关键信息
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基因名
TRIM58
- 应用
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别名
BIA2; DKFZp434C091; Protein BIA2; TRI58_HUMAN; Trim58; Tripartite motif-containing Protein 58
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NG06
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表达区间
1-486 aa
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氨基酸序列
MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA GPEHRTHRTA PLQEAAGSYQ VKLQMALELM RKELEDALTQ EANVGKKTVI WKEKVEMQRQ RFRLEFEKHR GFLAQEEQRQ LRRLEAEERA TLQRLRESKS RLVQQSKALK ELADELQERC QRPALGLLEG VRGVLSRSKA VTRLEAENIP MELKTACCIP GRRELLRKFQ VDVKLDPATA HPSLLLTADL RSVQDGEPWR DVPNNPERFD TWPCILGLQS FSSGRHYWEV LVGEGAEWGL GVCQDTLPRK GETTPSPENG VWALWLLKGN EYMVLASPSV PLLQLESPRC IGIFLDYEAG EISFYNVTDG SYIYTFNQLF SGLLRPYFFI CDATPLILPP TTIAGSGNWA SRDHLDPASD VRDDHL
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分子量
54.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TRIM58, a member of the tripartite motif (TRIM) protein family, plays a significant role in various cellular processes, including immune response, apoptosis, and cell cycle regulation. The TRIM family is characterized by a RING domain, one or two B-boxes, and a coiled-coil region, which enables them to mediate protein ubiquitination and regulate protein stability. Recent studies have implicated TRIM58 in the modulation of inflammatory responses and its potential links to various diseases, including cancer and autoimmune disorders. Research has revealed that TRIM58 can act as an E3 ubiquitin ligase, targeting specific substrates for ubiquitination and subsequent degradation, thus influencing various signaling pathways. Additionally, TRIM58 has been associated with the regulation of viral infections, suggesting its role in host-pathogen interactions. Understanding the mechanisms through which TRIM58 operates not only provides insights into its biological functions but also highlights its potential as a therapeutic target in diseases where these pathways are dysregulated. Given the increasing interest in the roles of E3 ubiquitin ligases in disease processes and their potential in drug discovery, TRIM58 represents a promising candidate for further research aimed at uncovering its full biological and clinical significance.
