关键信息
-
基因名
FOXC1
- 应用
-
别名
FOXC1；FKHL7；FREAC3；Forkhead box Protein C1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q12948
-
表达区间
1-553aa
-
氨基酸序列
MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGGMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKDRLHLKEPPPPGRQPPPAPPEQADGNAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAAAVPKIESPDSSSSSLSSGSSPPGSLPSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAAELSSGLLASAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQTSSAGSSGGGGGGAGAAGGAGGAGTYHCNLQAMSLYAAGERGGHLQGAPGGAGGSAVDDPLPDYSLPPVTSSSSSSLSHGGGGGGGGGGQEAGHHPAAHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSVREMFESQRIGLNNSPVNGNSSCQMAFPSSQSLYRTSGAFVYDCSKF
-
分子量
62.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
FOXC1 (Forkhead box C1) is a member of the forkhead box transcription factor family, playing a pivotal role in various biological processes, including embryogenesis, cell differentiation, and tissue repair. Recent studies have implicated FOXC1 in several diseases, particularly in cancer and cardiovascular conditions, highlighting its function in regulating cell proliferation, migration, and survival. Abnormal expression of FOXC1 has been associated with an aggressive tumor phenotype in various cancers, making it a potential biomarker for disease progression and a target for therapeutic interventions. Furthermore, FOXC1 is crucial in ocular development, with mutations linked to congenital glaucoma and other eye disorders. The recombinant expression of FOXC1 protein is essential for understanding its functional mechanisms and regulatory pathways, as well as for exploring its potential as a therapeutic target. Research involving FOXC1 recombination has advanced our knowledge of transcriptional regulation, signaling pathways, and the intricate network of gene interactions in both health and disease. By producing and characterizing FOXC1 recombinant protein, scientists aim to develop novel strategies for targeting its activity and investigating its role in pathophysiological contexts. Such efforts contribute significantly to the understanding of FOXC1’s role in development and disease, paving the way for future diagnostic and therapeutic applications.
