关键信息
-
基因名
WDR22
- 应用
-
别名
BCRG2; BCRP2; Breakpoint cluster region Protein 2; Breakpoint cluster region Protein; uterine leiomyoma; 2; D14S1461E; Dcaf5; DCAF5_HUMAN; DDB1 and CUL4 associated factor 5; DDB1- and CUL4-associated factor 5; WD repeat-containing Protein 22; WDR22
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q96JK2
-
表达区间
1-326 aa
-
氨基酸序列
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQHHNWKWRAQAVSFQPFLSLTRNGDADVDLKLAV
-
分子量
63 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
WDR22, or WD repeat domain 22, is a protein that belongs to the WD repeat protein family, characterized by the presence of multiple WD repeats, which are typically involved in protein-protein interactions and play a crucial role in various cellular processes. Research has shown that WDR22 is implicated in essential biological functions, including gene regulation, cell cycle control, and signal transduction. It is expressed in a variety of tissues and has been linked to several disease states, particularly in cancer, where its dysregulation may contribute to tumor progression. Furthermore, studies suggest that WDR22 may be involved in the modulation of immune responses and has potential implications in autoimmune diseases. Given its significant roles, the recombinant expression of WDR22 is critical for detailed functional analysis and for exploring its potential as a therapeutic target. Investigating the structure and function of WDR22 through recombinant protein studies can provide insights into its specific interactions and mechanisms, potentially revealing novel pathways for intervention in diseases where WDR22 is implicated. Thus, the study of WDR22 as a recombinant protein is essential for understanding its biological significance and for developing strategies aimed at manipulating its activity for therapeutic benefits. This area of research not only enhances our understanding of fundamental cellular processes but also paves the way for potential clinical applications in targeted therapies.
