关键信息
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基因名
WDR18
- 应用
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别名
Involved in Processing ITS2 3 homolog; Ipi3; MGC2436; R32184_1; WD repeat domain 18; WD repeat-containing Protein 18; Wdr18; WDR18_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BV38
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表达区间
1-432 aa
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氨基酸序列
MAAPMEVAVC TDSAAPMWSC IVWELHSGAN LLTYRGGQAG PRGLALLNGE YLLAAQLGKN YISAWELQRK DQLQQKIMCP GPVTCLTASP NGLYVLAGVA ESIHLWEVST GNLLVILSRH YQDVSCLQFT GDSSHFISGG KDCLVLVWSL CSVLQADPSR IPAPRHVWSH HALPITDLHC GFGGPLARVA TSSLDQTVKL WEVSSGELLL SVLFDVSIMA VTMDLAEHHM FCGGSEGSIF QVDLFTWPGQ RERSFHPEQD AGKVFKGHRN QVTCLSVSTD GSVLLSGSHD ETVRLWDVQS KQCIRTVALK GPVTNAAILL APVSMLSSDF RPSLPLPHFN KHLLGAEHGD EPRHGGLTLR LGLHQQGSEP SYLDRTEQLQ AVLCSTMEKS VLGGQDQLRV RVTELEDEVR NLRKINRDLF DFSTRFITRP AK
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分子量
47.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
WDR18, or WD repeat-containing protein 18, is a member of the WD40-repeat protein family, which is known for its role in various cellular processes, including signal transduction, cell cycle regulation, and protein-protein interactions. Research into WDR18 has gained prominence due to its involvement in essential biological functions and potential implications in various diseases, including cancer. The protein has been shown to play a crucial role in the regulation of the cell cycle and gene expression, often functioning as a co-factor or scaffold for protein complexes. Its unique structural features, particularly the presence of WD40 repeats, enable it to interact with a diverse array of proteins, influencing various signaling pathways. Additionally, studies indicate that WDR18 may participate in the regulation of cellular stress responses and apoptosis. Given its significant role in cellular dynamics, understanding the structure and function of WDR18 through recombinant protein studies is pivotal. Such investigations can unveil its molecular mechanisms, facilitate the discovery of potential biomarkers, and pave the way for targeted therapeutic strategies, especially in diseases where WDR18 is implicated. Therefore, the recombinant expression and functional characterization of WDR18 are crucial for elucidating its biological significance and exploring its potential as a therapeutic target.
