关键信息
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基因名
SUCNR1
- 应用
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别名
G-protein coupled receptor 91;P2Y purinoceptor 1-like
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BXA5
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表达区间
1-334 aa
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氨基酸序列
MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
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分子量
40.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The SUCNR1 gene encodes a receptor known as the succinate receptor 1, which plays a crucial role in various physiological processes, including the regulation of metabolism and inflammation. Research has indicated that SUCNR1 is involved in sensing metabolic changes in the body, particularly in response to succinate, a key intermediate in the tricarboxylic acid cycle. Abnormal SUCNR1 signaling has been implicated in several pathological conditions, including cardiovascular diseases, cancer, and metabolic disorders. Consequently, the study of SUCNR1 recombinant proteins has gained significant attention as a potential therapeutic target. Recombinant SUCNR1 proteins allow for the investigation of receptor function, ligand interaction, and downstream signaling pathways in controlled experimental settings. Understanding the structure and dynamics of SUCNR1 via recombinant technologies can provide insights into its role in disease mechanisms and may aid in the development of novel therapeutic approaches that modulate its activity. Furthermore, the production of SUCNR1 proteins in heterologous systems facilitates high-throughput screening of small molecules that could serve as SUCNR1 modulators, aiming to uncover new treatment strategies for various conditions associated with dysregulated succinate signaling. Overall, the research on SUCNR1 recombinant proteins is vital for unraveling the complexities of succinate signaling in health and disease, paving the way for innovative biomedical applications.
