关键信息
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基因名
DMRTC1
- 应用
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别名
DMRTC1;; DMRTC1BDoublesex- and mab-3-related transcription factor C1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5HYR2
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表达区间
1-192aa
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氨基酸序列
MAAPPKAPIRVRNLTIRAGALTGKENNMLQPETHIFTAPEEGSSQGALLLGQAPEPLSLPCTPVTLEQQLVSPSGDPHRAPALPSICSTLILQPCATLDPLLLQPQVPKVSDQALVSAHSEWQRKLEAAEALLTLRNSAQAPPDSISLHQPCNPPAPAGDKGFQPPSPSLRPRPASSISLPIGHLGCISLLS
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分子量
21.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
DMRTC1, a member of the DMRT (Doublesex and Mab-3 related transcription factor) gene family, has gained attention in recent years for its critical role in sexual development and differentiation across various species. Initially identified in Drosophila, the DMRT proteins are known to regulate sex-specific traits and developmental pathways, which has implications for understanding sexual dimorphism. In vertebrates, DMRTC1 has been linked to the regulation of testis development and spermatogenesis, making it a candidate for studying male fertility and associated disorders. Research indicates that mutations or dysregulation of DMRTC1 can lead to abnormalities in gonadal development and function. Additionally, its expression patterns in different tissues suggest a broader role in development beyond reproductive organs. Investigations into the molecular mechanisms underlying DMRTC1 function and its interactions with other genes are crucial for elucidating its role in both normal biology and pathological conditions, such as intersex disorders and infertility. Understanding the pathways and targets of DMRTC1 could provide insights into novel therapeutic strategies for reproductive health issues and enhance our knowledge of evolutionary biology regarding sex differentiation. As research on DMRTC1 advances, it holds potential for significant contributions to the fields of developmental biology, genetics, and reproductive medicine.
