| 经过测试的应用 | |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 反应物种 | Mouse |
| SwissProt ID | Q62386 |
| 抗体类型 | Monoclonal Antibody |
| 克隆性 | Monoclonal |
| 宿主 | Rabbit |
| 基因名 | Mouse IL-17A |
| 背景信息 | IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
| 形式 | Liquid |
| 存储缓冲液 | 0.01M PBS, pH 7.2 |
| 储存 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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