关键信息
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基因名
SLC25A46
- 应用
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别名
SLC25A46; TB1; Solute carrier family 25 member 46
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96AG3
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表达区间
1-418 aa
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氨基酸序列
MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTSTPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISSVIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI
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分子量
72.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
SLC25A46 is a gene encoding a mitochondrial carrier protein that has garnered attention due to its role in mitochondrial function and the pathogenesis of neurodegenerative diseases. Mutations in SLC25A46 are linked to conditions such as early-onset progressive ataxia and neuropathy, suggesting its critical involvement in maintaining mitochondrial integrity and function. Research has shown that SLC25A46 plays a pivotal role in the regulation of mitochondrial dynamics, particularly in the processes of mitochondrial fusion and fission. Understanding the structure and function of the SLC25A46 recombinant protein is essential to elucidate its mechanisms in mitochondrial biology and disease. Recent studies employing recombinant protein techniques have aimed to characterize SLC25A46, exploring its transport capabilities and interactions with other mitochondrial proteins. This knowledge is vital for developing potential therapeutic strategies targeting mitochondrial dysfunctions associated with SLC25A46 mutations. The investigation of SLC25A46 as a biochemical entity not only enhances our understanding of basic mitochondrial biology but also sheds light on its clinical significance, paving the way for new approaches in treating mitochondrial-related diseases.
