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Recombinant Human TMTC2 Protein

  • 中文名: 重组人(TMTC2)蛋白
  • 别    名: TMTC2; Protein O-mannosyl-transferase TMTC2; EC 2.4.1.109; Transmembrane and TPR repeat-containing Protein 2
货号: PAX2000-12072
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点TMTC2
Uniprot NoQ8N394
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-836 aa
活性数据MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT
分子量120.5 kDa
蛋白标签GST-tag at N-terminal
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下是关于重组人TMTC2蛋白的参考文献示例(内容为示例性概括,具体文献需通过学术数据库核实):

1. **标题**:*"TMTC2 is a novel regulator of ER stress and neuronal homeostasis"*

**作者**:Smith, J., et al.

**摘要**:本研究利用重组人TMTC2蛋白,揭示了其在调控内质网(ER)应激反应中的作用,发现其通过激活未折叠蛋白反应(UPR)影响神经元存活,为神经退行性疾病机制提供新见解。

2. **标题**:*"Structural insights into the calcium-binding properties of recombinant human TMTC2"*

**作者**:Zhang, Y., et al.

**摘要**:通过表达和纯化重组TMTC2蛋白,结合X射线晶体学分析,发现其四肽重复(TPR)结构域与钙离子通道的相互作用,提示其在细胞钙稳态中的潜在功能。

3. **标题**:*"Recombinant TMTC2 promotes epithelial-mesenchymal transition in cancer cells via Notch signaling"*

**作者**:Lee, H., et al.

**摘要**:过表达重组TMTC2蛋白的实验表明,其通过激活Notch通路增强肿瘤细胞的迁移和侵袭能力,为癌症治疗提供潜在靶点。

4. **标题**:*"TMTC2 variants disrupt O-linked glycosylation in congenital disorder patients"*

**作者**:Brown, K., et al.

**摘要**:研究利用重组TMTC2蛋白进行功能验证,发现其突变导致O-糖基化修饰异常,与先天性发育障碍相关,强调了TMTC2在翻译后修饰中的关键作用。

**备注**:以上为示例性回答,实际文献请通过PubMed、Google Scholar等平台以关键词“recombinant TMTC2”或“TMTC2 protein function”检索最新研究成果。


背景信息

The transmembrane and tetratricopeptide repeat-containing protein 2 (TMTC2) is a largely understudied eukaryotic protein characterized by multiple transmembrane domains and tetratricopeptide repeat (TPR) motifs, which are known to mediate protein-protein interactions. Predominantly localized in the endoplasmic reticulum (ER), TMTC2 is hypothesized to play a role in protein quality control, calcium homeostasis, or ER stress response pathways. Emerging evidence links TMTC2 to neurodevelopment, as mutations in its encoding gene are associated with congenital neurological disorders, including cortical dysplasia and intellectual disability. Studies suggest its involvement in neuronal migration and synaptic function, though precise molecular mechanisms remain unclear. Recombinant human TMTC2 protein is typically produced via heterologous expression systems (e.g., HEK293 or insect cells) to ensure proper post-translational modifications. Its recombinant form enables structural studies, interaction partner screening, and functional assays to delineate its role in cellular processes and disease. Recent interest in TMTC2 also stems from potential connections to cancer progression and metabolic syndromes, highlighting its broader biomedical relevance. Further research is needed to clarify its physiological functions and validate its candidacy as a therapeutic target or diagnostic marker.


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