| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TMEM39B |
| Uniprot No | Q9GZU3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-365 aa |
| 活性数据 | MVTTIVLGRRFIGSIVKEASQRGKVSLFRSILLFLTRFTVLTATGWSLCRSLIHLFRTYSFLNLLFLCYPFGMYIPFLQLNCDLRKTSLFNHMASMGPREAVSGLAKSRDYLLTLRETWKQHTRQLYGPDAMPTHACCLSPSLIRSEVEFLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKNTHYYDKRWSCELFLLVSISTSVILMQHLLPASYCDLLHKAAAHLGCWQKVDPALCSNVLQHPWTEECMWPQGVLVKHSKNVYKAVGHYNVAIPSDVSHFRFHFFFSKPLRILNILLLLEGAVIVYQLYSLMSSEKWHQTISLALILFSNYYAFFKLLRDRLVLGKAYSYSASPQRDLDHRFS |
| 分子量 | 68.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇关于TMEM39B蛋白的假想参考文献示例(注：文献为虚拟构造，实际研究请以真实数据库为准)：
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1. **文献名称**：*TMEM39B基因多态性与系统性红斑狼疮的遗传关联*
**作者**：Zhang Y. et al.
**摘要**：研究发现TMEM39B单核苷酸多态性(SNP)与系统性红斑狼疮(SLE)的易感性显著相关，提示该蛋白可能通过调控免疫细胞的自噬通路参与自身免疫反应。
2. **文献名称**：*TMEM39B调控HIV-1病毒颗粒释放的机制*
**作者**：Suthar N. et al.
**摘要**：TMEM39B被鉴定为参与HIV-1病毒出芽过程的关键宿主因子，其通过影响细胞膜脂质重组促进病毒粒子释放，沉默TMEM39B显著抑制病毒复制。
3. **文献名称**：*TMEM39B在乳腺癌中的功能及临床意义*
**作者**：Li H. et al.
**摘要**：TMEM39B在乳腺癌组织中高表达，与患者预后不良相关。体外实验表明其通过激活PI3K/AKT通路促进肿瘤细胞增殖和迁移。
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如需真实文献，建议检索PubMed或Web of Science数据库，以“TMEM39B”为关键词筛选近年研究。
Transmembrane protein 39B (TMEM39B) is a ubiquitously expressed, multi-pass membrane protein encoded by the TMEM39B gene located on human chromosome 1. Structurally, it contains conserved transmembrane domains and a cytosolic N-terminal region, suggesting roles in intracellular membrane trafficking or organelle organization. Though its precise molecular function remains understudied, emerging evidence links TMEM39B to autophagy regulation, lysosomal function, and immune responses. Genome-wide association studies (GWAS) have identified TMEM39B as a susceptibility locus for autoimmune diseases, including systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Dysregulation of TMEM39B is proposed to disrupt immune tolerance, potentially via altered vesicular trafficking in antigen-presenting cells or cytokine signaling.
Recombinant human TMEM39B protein is typically produced using mammalian expression systems (e.g., HEK293 cells) to ensure proper post-translational modifications. It is utilized to investigate protein-protein interactions, antibody development, and functional assays exploring its role in autophagy or immune pathways. Recent studies also implicate TMEM39B in viral infection mechanisms, highlighting its interaction with viral capsid proteins. Despite its emerging biomedical relevance, further structural and mechanistic studies are needed to clarify its physiological and pathological contributions, offering potential therapeutic insights for autoimmune and inflammatory disorders.
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