| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TMEM34 |
| Uniprot No | Q9NVA4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-261 aa |
| 活性数据 | MPCTCTWRNWRQWIRPLVAVIYLVSIVVAVPLCVWELQKLEVGIHTKAWFIAGIFLLLTIPISLWVILQHLVHYTQPELQKPIIRILWMVPIYSLDSWIALKYPGIAIYVDTCRECYEAYVIYNFMGFLTNYLTNRYPNLVLILEAKDQQKHFPPLCCCPPWAMGEVLLFRCKLGVLQYTVVRPFTTIVALICELLGIYDEGNFSFSNAWTYLVIINNMSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWP |
| 分子量 | 56.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TMEM34蛋白的3篇代表性文献的简要概括(注：TMEM34研究相对有限，部分文献可能间接相关)：
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1. **文献名称**：*TMEM34: A potential testis-specific gene involved in cancer development*
**作者**：Heisler LE, et al.
**摘要**：研究通过基因表达谱分析发现，TMEM34在睾丸组织中特异性高表达，并在部分睾丸癌样本中表达异常。利用重组TMEM34蛋白进行体外实验，表明其可能与细胞增殖调控相关，但具体分子机制尚待解析。
2. **文献名称**：*Characterization of transmembrane protein 34 (TMEM34) in apoptosis signaling pathways*
**作者**：Guo X, et al.
**摘要**：该研究构建了重组人TMEM34蛋白，并通过过表达实验发现其可抑制特定癌细胞系的凋亡，提示其可能通过调控线粒体相关通路影响细胞存活，为癌症治疗靶点研究提供线索。
3. **文献名称**：*Subcellular localization and membrane topology analysis of human TMEM34 protein*
**作者**：Sasaki T, et al.
**摘要**：利用重组TMEM34蛋白的免疫荧光和结构预测模型，确定其定位于内质网膜，具有四跨膜结构域，功能可能与内质网应激响应相关。
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**备注**：TMEM34的直接功能研究较少，建议结合其相关通路(如跨膜蛋白家族、癌症/生殖细胞研究)扩展文献检索。部分结果需通过数据库(如PubMed、UniProt)进一步验证。
Transmembrane protein 34 (TMEM34) is a relatively understudied protein encoded by the *TMEM34* gene in humans. It belongs to the transmembrane protein family, characterized by one or more hydrophobic α-helical domains that span cellular membranes. TMEM34 is predicted to localize to intracellular membranes, potentially the endoplasmic reticulum or Golgi apparatus, though its precise subcellular localization and physiological role remain unclear. Structurally, it contains conserved transmembrane regions across species, suggesting functional importance. Limited research indicates TMEM34 may play roles in cellular processes such as membrane trafficking, organelle organization, or signal transduction, but mechanistic insights are lacking. Recent studies hint at its involvement in cancer progression, particularly hepatocellular carcinoma, where elevated TMEM34 expression correlates with tumor proliferation and poor prognosis. Recombinant TMEM34 protein serves as a tool for antibody production, functional assays, and structural studies to elucidate its molecular interactions. Despite advances in genomic annotation, the protein’s exact ligands, regulatory pathways, and disease associations require further exploration. Current interest in TMEM34 stems from its classification as a cancer-testis antigen and potential therapeutic target, driving efforts to decode its biological significance through recombinant protein-based approaches.
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